(±)-1,2-Propanediol
Based on 3 publication(s) in Google Scholar
(±)-1, 2-propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol that is often used as an excipient in many active molecular preparations to increase the solubility and stability of the active molecule. (±)-1, 2-propanediol can affect the neurobehavior of zebrafish.
For research use only. We do not sell to patients.
- Purity: 99.97%
- CAS No.: 57-55-6
- Formula: C3H8O2
- Molecular Weight:76.09
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) (±)-1,2-Propanediol
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
(±)-1,2-Propanediol (Propylene glycol) is a frequently used excipient in many drug formulations to increase the solubility and/or stability of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 57-55-6
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Appearance Liquid (Density: 1.036 g/cm3)
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Molecular Weight 76.09
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Formula C3H8O2
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Color Colorless to light yellow
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SMILES
CC(O)CO
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Synonyms
1,2-(RS)-Propanediol; 1,2-Propylene glycol; Propylene glycol
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Initial Source
Clostridium strain AK1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Publications (3)
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Journal Impact Factor
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Most Recent
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J Nanobiotechnology
Unveiling new therapeutic targets for esophageal cancer treatment through single-cell transcriptomics: pH-responsive nanobubbles enhance the efficacy of 125I radiotherapy. [Abstract]2025 Jul 15;23(1):515. PMID: 40665303 -
Commun Biol
Selective inhibition of HDAC class IIA as therapeutic intervention for KMT2A-rearranged acute lymphoblastic leukemia. [Abstract]2024 Oct 4;7(1):1257. PMID: 39362994 -
iScience
Roseburia intestinalis relieves intrahepatic cholestasis of pregnancy through bile acid/FXR-FGF15 in rats. [Abstract]2023 Nov 3;26(12):108392. PMID: 38025767
Solvent & Solubility
H2O : 100 mg/mL (1314.23 mM; Need ultrasonic)
DMSO : 100 mg/mL (1314.23 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (32.86 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. De Cock RF, et al. Low but inducible contribution of renal elimination to clearance of propylene glycol in preterm and term neonates. Ther Drug Monit. 2014 Jun;36(3):278-87. [Content Brief]
[2]. Massarsky A, et al. Neurobehavioral effects of 1,2-propanediol in zebrafish (Danio rerio). Neurotoxicology. 2018 Mar;65:111-124. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O / DMSO | 1 mM | 13.1423 mL | 65.7117 mL | 131.4233 mL | 328.5583 mL |
| 5 mM | 2.6285 mL | 13.1423 mL | 26.2847 mL | 65.7117 mL | |
| 10 mM | 1.3142 mL | 6.5712 mL | 13.1423 mL | 32.8558 mL | |
| 15 mM | 0.8762 mL | 4.3808 mL | 8.7616 mL | 21.9039 mL | |
| 20 mM | 0.6571 mL | 3.2856 mL | 6.5712 mL | 16.4279 mL | |
| 25 mM | 0.5257 mL | 2.6285 mL | 5.2569 mL | 13.1423 mL | |
| 30 mM | 0.4381 mL | 2.1904 mL | 4.3808 mL | 10.9519 mL | |
| 40 mM | 0.3286 mL | 1.6428 mL | 3.2856 mL | 8.2140 mL | |
| 50 mM | 0.2628 mL | 1.3142 mL | 2.6285 mL | 6.5712 mL | |
| 60 mM | 0.2190 mL | 1.0952 mL | 2.1904 mL | 5.4760 mL | |
| 80 mM | 0.1643 mL | 0.8214 mL | 1.6428 mL | 4.1070 mL | |
| 100 mM | 0.1314 mL | 0.6571 mL | 1.3142 mL | 3.2856 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
(±)-1,2-Propanediol Related Classifications
HY-Y0921 Related Classifications
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