(±)-1,2-Propanediol-d8
Based on 1 Customer Validation
(±)-1,2-Propanediol-d8 is the deuterium labeled (±)-1,2-Propanediol. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many agent formulations to increase the solubility and stability of agents.
For research use only. We do not sell to patients.
- Purity: 99.55%
- CAS No.: 80156-55-4
- Formula: C3D8O2
- Molecular Weight:84.14
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Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 80156-55-4
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Unlabeled CAS 57-55-6
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Appearance Liquid (Density: 1.036±0.06 g/cm3)
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Molecular Weight 84.14
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Formula C3D8O2
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Color Colorless to light yellow
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SMILES
[2H]OC([2H])([2H])C(O[2H])([2H])C([2H])([2H])[2H]
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Synonyms
1,2-(RS)-Propanediol-d8; 1,2-Propylene glycol-d8; Propylene glycol-d8
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 25 mg/mL (297.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. De Cock RF, et al. Low but inducible contribution of renal elimination to clearance of propylene glycol in preterm and term neonates. Ther Drug Monit. 2014 Jun;36(3):278-87. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 11.8850 mL | 59.4248 mL | 118.8495 mL | 297.1238 mL |
| 5 mM | 2.3770 mL | 11.8850 mL | 23.7699 mL | 59.4248 mL | |
| 10 mM | 1.1885 mL | 5.9425 mL | 11.8850 mL | 29.7124 mL | |
| 15 mM | 0.7923 mL | 3.9617 mL | 7.9233 mL | 19.8083 mL | |
| 20 mM | 0.5942 mL | 2.9712 mL | 5.9425 mL | 14.8562 mL | |
| 25 mM | 0.4754 mL | 2.3770 mL | 4.7540 mL | 11.8850 mL | |
| 30 mM | 0.3962 mL | 1.9808 mL | 3.9617 mL | 9.9041 mL | |
| 40 mM | 0.2971 mL | 1.4856 mL | 2.9712 mL | 7.4281 mL | |
| 50 mM | 0.2377 mL | 1.1885 mL | 2.3770 mL | 5.9425 mL | |
| 60 mM | 0.1981 mL | 0.9904 mL | 1.9808 mL | 4.9521 mL | |
| 80 mM | 0.1486 mL | 0.7428 mL | 1.4856 mL | 3.7140 mL | |
| 100 mM | 0.1188 mL | 0.5942 mL | 1.1885 mL | 2.9712 mL |
(±)-1,2-Propanediol-d8 Related Classifications
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