Acetyl-CoA Carboxylase-IN-1

Name: Acetyl-CoA Carboxylase-IN-1
Brand: MedChemExpress
SKU: HY-152117
Rating: 4.5 (0 reviews)

Cat. No.: HY-152117 Purity: 99.18%: Data Sheet
COA

SDS
Handling Instructions
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Acetyl-CoA Carboxylase-IN-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC₅₀ value of ＜5 nM. Acetyl-CoA Carboxylase-IN-1 has antibacterial activity.

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Acetyl-CoA Carboxylase-IN-1 화학구조

CAS No. : 179343-23-8

사이즈	재고	수량

무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

Acetyl-CoA Carboxylase-IN-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC₅₀ value of ＜5 nM. Acetyl-CoA Carboxylase-IN-1 has antibacterial activity^[1].

In Vitro

Acetyl-CoA Carboxylase-IN-1 (compound 1; 0.012-25 μM; E. coli) has antibacterial activity with MIC values of >25, 3.13, 25, 0.39, 1.56, 0.1 μM for WT, WT+ PMBN, ΔacrAB, ΔacrAB+PMBN, ΔtolC, and ΔtolC+ PMBN, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

395.05

화학식

C₁₃H₉Br₂N₅

CAS No.

179343-23-8

Appearance

Solid

Color

Off-white to light yellow

SMILES

BrC1=C(C2=CC3=CN=C(N=C3N=C2N)N)C(Br)=CC=C1

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 33.33 mg/mL (84.37 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5313 mL	12.6566 mL	25.3133 mL
5 mM	0.5063 mL	2.5313 mL	5.0627 mL
10 mM	0.2531 mL	1.2657 mL	2.5313 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.18%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (249 KB) HNMR (131 KB) LCMS (172 KB)

Handling Instructions (2659 KB)

References

[1]. Cifone MT, et, al. Heterobivalent Inhibitors of Acetyl-CoA Carboxylase: Drug Target Residence Time and Time-Dependent Antibacterial Activity. J Med Chem. 2022 Dec 22;65(24):16510-16525. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5313 mL	12.6566 mL	25.3133 mL	63.2831 mL
	5 mM	0.5063 mL	2.5313 mL	5.0627 mL	12.6566 mL
	10 mM	0.2531 mL	1.2657 mL	2.5313 mL	6.3283 mL
	15 mM	0.1688 mL	0.8438 mL	1.6876 mL	4.2189 mL
	20 mM	0.1266 mL	0.6328 mL	1.2657 mL	3.1642 mL
	25 mM	0.1013 mL	0.5063 mL	1.0125 mL	2.5313 mL
	30 mM	0.0844 mL	0.4219 mL	0.8438 mL	2.1094 mL
	40 mM	0.0633 mL	0.3164 mL	0.6328 mL	1.5821 mL
	50 mM	0.0506 mL	0.2531 mL	0.5063 mL	1.2657 mL
	60 mM	0.0422 mL	0.2109 mL	0.4219 mL	1.0547 mL
	80 mM	0.0316 mL	0.1582 mL	0.3164 mL	0.7910 mL