AMX12006

Name: AMX12006
Brand: MedChemExpress
SKU: HY-149290
Rating: 4.5 (0 reviews)

Art. -Nr.: HY-149290 Reinheit: 99.9%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

AMX12006 is a potent, selective and orally active EP4 antagonist with an IC₅₀ value of 4.3 nM. AMX12006 shows cytotoxic and antitumor activity.

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AMX12006 Chemische Struktur

CAS. Nr. : 2639775-01-0

Größe	Verfügbarkeit	Menge
1 mg	Auf Lager	Estimated Time of Arrival: December 31
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
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100 mg	Angebot einholen

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Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Prostaglandin Receptor Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

DP EP FP IP TXA₂/TP TXB₂

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

AMX12006 is a potent, selective and orally active EP4 antagonist with an IC₅₀ value of 4.3 nM. AMX12006 shows cytotoxic and antitumor activity^[1].

IC₅₀ & Target^[1]

hEP4

4.3 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
4T1	IC₅₀	79.47 μM Compound: 36; AMX12006	Cytotoxicity against mouse 4T1 cells assessed as inhibition of cell growth measured after 72 hrs by Cell-titer glo assay Cytotoxicity against mouse 4T1 cells assessed as inhibition of cell growth measured after 72 hrs by Cell-titer glo assay	[PMID: 37312837]
CT26.WT	IC₅₀	41.39 μM Compound: 36; AMX12006	Cytotoxicity against mouse CT26.WT cells assessed as inhibition of cell growth measured after 72 hrs by Cell-titer glo assay Cytotoxicity against mouse CT26.WT cells assessed as inhibition of cell growth measured after 72 hrs by Cell-titer glo assay	[PMID: 37312837]
Lewis lung carcinoma cell line	IC₅₀	>100 μM Compound: 36; AMX12006	Cytotoxicity against mouse Lewis lung carcinoma cell line assessed as inhibition of cell growth measured after 72 hrs by Cell-titer glo assay Cytotoxicity against mouse Lewis lung carcinoma cell line assessed as inhibition of cell growth measured after 72 hrs by Cell-titer glo assay	[PMID: 37312837]
MCF7	IC₅₀	46.73 μM Compound: 36; AMX12006	Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by Cell-titer glo assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by Cell-titer glo assay	[PMID: 37312837]

In Vitro

AMX12006 (compound 36) (0-100 µM) shows cytotoxic with IC₅₀s of 46.73, 79.47, >100, 41.39, >100 µM for MCF-7, 4T1, HCA-7, CT-26 WT, LLC cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	MCF-7, 4T1, HCA-7, CT-26 WT, LLC cells
Concentration:	0-100 µM
Incubation Time:
Result:	Showed cytotoxic with IC₅₀s of 46.73, 79.47, >100, 41.39, >100 µM for MCF-7, 4T1, HCA-7, CT-26 WT, LLC cells, respectively.

In Vivo

AMX12006 (75, 150 mg/kg; p.o.; once daily for 11 days) shows antitumor activity in a dose-dependent manner^[1].
Pharmacokinetic Parameters of AMX12006 in Sprague-Dawley rats^[1].

	iv, 1 mg/kg	po, 10 mg/kg
T_max (h)		0.5
C_max (ng/mL)	4627 ± 304	8243 ± 370
AUC_(0-t)(h·ng/mL)	3375 ± 477	25672 ± 5668
AUC_0–∞ (h·ng/mL)	3416 ± 495	25707 ± 5682
T_1/2(h)	1.4 ± 0.3	2.7 ± 0.2
CL (mL/min/kg)	4.95 ± 0.77
Vdss (L/kg)	0.41 ± 0.04
F %		76.1

Sprague-Dawley rats, 1 mg/kg iv ; 10 mg/kg po^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

481.47

Formel

C₂₆H₂₂F₃N₃O₃

CAS. Nr.

2639775-01-0

Appearance

Solid

Color

White to light yellow

SMILES

O=C(N[C@@H](C)C1=CC=C(C(O)=O)C=C1)C2=C(C3=CC=CC=C3N2C)NC4=CC(C(F)(F)F)=CC=C4

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMF : 20 mg/mL (41.54 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0770 mL	10.3849 mL	20.7697 mL
5 mM	0.4154 mL	2.0770 mL	4.1539 mL
10 mM	0.2077 mL	1.0385 mL	2.0770 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 99.9%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (254 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Debasis Das, et al. Discovery of Novel, Selective Prostaglandin EP4 Receptor Antagonists with Efficacy in Cancer Models. ACS Med. Chem. Lett. 2023.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMF	1 mM	2.0770 mL	10.3849 mL	20.7697 mL	51.9243 mL
	5 mM	0.4154 mL	2.0770 mL	4.1539 mL	10.3849 mL
	10 mM	0.2077 mL	1.0385 mL	2.0770 mL	5.1924 mL
	15 mM	0.1385 mL	0.6923 mL	1.3846 mL	3.4616 mL
	20 mM	0.1038 mL	0.5192 mL	1.0385 mL	2.5962 mL
	25 mM	0.0831 mL	0.4154 mL	0.8308 mL	2.0770 mL
	30 mM	0.0692 mL	0.3462 mL	0.6923 mL	1.7308 mL
	40 mM	0.0519 mL	0.2596 mL	0.5192 mL	1.2981 mL

AMX12006 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMX120062639775-01-0AMX 12006AMX-12006Prostaglandin Receptororally activecytotoxicantitumorCT-26 cellsInhibitorinhibitorinhibit

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AMX12006

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AMX12006 Related Antibodies

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Prostaglandin Receptor Isoform-spezifische Produkte anzeigen:

Biologische Aktivität

Reinheit & Dokumentation

Verweise

Kundenbewertung

AMX12006 Related Antibodies

Molaritätsrechner

Verdünnungsrechner

Complete Stock Solution Preparation Table

AMX12006 Related Classifications

Keywords:

Ihre kürzlich angesehenen Produkte:

Kundenbewertung

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SAFETY DATA SHEET (SDS)

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