2. Membrane Transporter/Ion Channel
  3. Chloride Channel
  4. Ani9

Ani9 is an ANO1 inhibitor, with an IC50 of 77 nM. Ani9 can inhibit smooth muscle contractions in mice and is applicable in research related to diseases such as tumors.

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Ani9

Ani9 構造式

CAS 番号 : 356102-14-2

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 104 在庫あり
Solution
10 mM * 1 mL in DMSO USD 104 在庫あり
Solid
5 mg $95 在庫あり
10 mg $165 在庫あり
25 mg $345 在庫あり
50 mg $580 在庫あり
100 mg $980 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 2 publication(s) in Google Scholar

Ani9 関連抗体

Top Publications Citing Use of Products

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Ani9 is an ANO1 inhibitor, with an IC50 of 77 nM. Ani9 can inhibit smooth muscle contractions in mice and is applicable in research related to diseases such as tumors[1][2][3].

Cellular Effect
Cell Line Type Value Description References
U138-MG GI50
32.44 3
Compound: 3
Antiproliferative activity against human U138 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U138 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
[PMID: 32906067]
U138-MG GI50
32.44 3
Compound: 3
Antiproliferative activity against human U138 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U138 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
[PMID: 32906067]
U-251 GI50
18.06 3
Compound: 3
Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability in presence of temozolomide measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability in presence of temozolomide measured after 72 hrs by Celltiter-glo assay
[PMID: 32906067]
U-251 GI50
18.06 3
Compound: 3
Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability in presence of temozolomide measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability in presence of temozolomide measured after 72 hrs by Celltiter-glo assay
[PMID: 32906067]
U-251 GI50
36.48 3
Compound: 3
Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
[PMID: 32906067]
U-251 GI50
36.48 3
Compound: 3
Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
[PMID: 32906067]
U-251 GI50
18.06 3
Compound: 3
Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability in presence of temozolomide measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability in presence of temozolomide measured after 72 hrs by Celltiter-glo assay
[PMID: 32906067]
U-87MG ATCC GI50
32.98 3
Compound: 3
Antiproliferative activity against human U87MG cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U87MG cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
[PMID: 32906067]
U-87MG ATCC GI50
32.98 3
Compound: 3
Antiproliferative activity against human U87MG cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U87MG cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
[PMID: 32906067]
U-251 GI50
36.48 3
Compound: 3
Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
[PMID: 32906067]
U-87MG ATCC GI50
32.98 3
Compound: 3
Antiproliferative activity against human U87MG cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U87MG cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
[PMID: 32906067]
U138-MG GI50
32.44 3
Compound: 3
Antiproliferative activity against human U138 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U138 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
[PMID: 32906067]
体外実験

Ani9 (0-30 μM, 20 min) does not affect the increase of cytoplasmic calcium induced by ATP in FRT cells[1].
Ani9 (1-10 μM, 20 min) inhibits ANO1[1].
Ani9 (0.03-10 μM, 20 min) inhibits CaCC current in PC3, Capan-1, and NHNE cells in a dose-dependent manner, with an IC50 of 110 nM[1].
Ani9 (0-10 μM, 24 h) highly expresses ANO1 in PC3 cells[2].
Ani9 (0.01-10 μM, 48 h) inhibits weakly in prostate cancer, breast cancer, and pancreatic cancer cells[2].
Ani9 (1 μM) inhibits Ca2+-activated Cl- (Clca) in portal vein smooth muscle of Cav1-KO mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ani9 関連抗体

Western Blot Analysis[2]

Cell Line: PC3
Concentration: 0, 3, 10 μM
Incubation Time: 24 h
Result: Expressed ANO1.

Cell Viability Assay[2]

Cell Line: PC3, MCF-7, BxPC3
Concentration: 0.01, 0.1, 1, 10 μM
Incubation Time: 48 h
Result: Had a weak inhibitory effect on cells.
分子量

332.78

分子式

C17H17ClN2O3
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(COC1=CC=C(C=C1C)Cl)N/N=C/C2=CC=CC=C2OC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : ≥ 125 mg/mL (375.62 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0050 mL 15.0249 mL 30.0499 mL
5 mM 0.6010 mL 3.0050 mL 6.0100 mL
10 mM 0.3005 mL 1.5025 mL 3.0050 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0050 mL 15.0249 mL 30.0499 mL 75.1247 mL
5 mM 0.6010 mL 3.0050 mL 6.0100 mL 15.0249 mL
10 mM 0.3005 mL 1.5025 mL 3.0050 mL 7.5125 mL
15 mM 0.2003 mL 1.0017 mL 2.0033 mL 5.0083 mL
20 mM 0.1502 mL 0.7512 mL 1.5025 mL 3.7562 mL
25 mM 0.1202 mL 0.6010 mL 1.2020 mL 3.0050 mL
30 mM 0.1002 mL 0.5008 mL 1.0017 mL 2.5042 mL
40 mM 0.0751 mL 0.3756 mL 0.7512 mL 1.8781 mL
50 mM 0.0601 mL 0.3005 mL 0.6010 mL 1.5025 mL
60 mM 0.0501 mL 0.2504 mL 0.5008 mL 1.2521 mL
80 mM 0.0376 mL 0.1878 mL 0.3756 mL 0.9391 mL
100 mM 0.0300 mL 0.1502 mL 0.3005 mL 0.7512 mL
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Ani9 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ani9356102-14-2Ani 9Ani-9Chloride ChannelCl− ChannelsAnoctamin 1 (ANO1)InhibitorAnticancer agentinhibitorinhibit

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製品名:
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製品番号:
HY-119981
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