2. Immunology/Inflammation
  3. IFNAR
  4. Anifrolumab

Anifrolumab  (Synonyms: MDX-1333; MEDI-546)

製品番号: HY-P99168 純度: 99.79%
COA Technical Support

Anifrolumab is a type I interferon (IFN) receptor antagonist, a human monoclonal antibody. Anifrolumab blocks the activity of type I interferon. Anifrolumab can be used in systemic lupus erythematosus (SLE) research.

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CAS 番号 : 1326232-46-5

容量 価格（税別） 在庫状況 数量
>無料サンプル (100 μg)   今すぐ申し込む  
1 mg $240 在庫あり
5 mg $540 在庫あり
10 mg $850 在庫あり
25 mg $1600 在庫あり
50 mg $2500 在庫あり
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200 mg   お問い合わせ  

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カスタマーレビュー

Based on 3 publication(s) in Google Scholar

Anifrolumab Featured Recommendations:

Anifrolumab 関連抗体

Top Publications Citing Use of Products

    Anifrolumab purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Aug 26;15(1):7165.  [Abstract]

    Anifrolumab (10 µg/ml, 2 h) suppressed PDCD1 gene expression in A2058 human melanoma cells.

    Anifrolumab purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Aug 26;15(1):7165.  [Abstract]

    Anifrolumab (10 µg/ml, 2 h) suppressed IFN-α-dependent PD-1 expression in A2058 human melanoma cells.

    Anifrolumab purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2025 Mar;58(3):e13762.  [Abstract]

    Anifrolumab (1 or 10 µg/ml) reversed the H/R‑induced increase in the secretion of type I IFNs (including IFN‑α and IFN‑β) into the culture medium of ventricular cardiac organoids and co‑cultured THP‑1 cells.

    Anifrolumab purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2025 Mar;58(3):e13762.  [Abstract]

    Anifrolumab (1 or 10 µg/ml) downregulated the expression of type I IFN-related genes in ventricular cardiac organoids and co‑cultured THP‑1 cells.

    Anifrolumab purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2025 Mar;58(3):e13762.  [Abstract]

    Anifrolumab (1 or 10 µg/ml) decreased the H/R‑induced proportion of CD86+ cells and the mean fluorescence intensity of CD86 protein in ventricular cardiac organoids and co-cultured THP-1 cells.

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    • 純度とドキュメンテーション

    • 参考文献

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    製品説明

    Anifrolumab is a type I interferon (IFN) receptor antagonist, a human monoclonal antibody. Anifrolumab blocks the activity of type I interferon. Anifrolumab can be used in systemic lupus erythematosus (SLE) research[1][2].

    Isotype

    Human IgG1 (L234F/L235E/P331S) kappa
    Recommend Isotype Controls
    Species Reactivity

    Human
    IC50 & Target

    IFNAR1
    体外実験

    Anifrolumab (67.7 nM; 20 min) induces sustained reduction of surface IFNAR1 and abrogates STAT1 phosphorylation[2].
    Anifrolumab (1 and 10 μg/mL; 6 or 7 d) suppresses differentiation of B cells into plasma cells[2].
    Anifrolumab inhibits type I IFN-induced ISRE signaling, with IC50s ranging from 0.004 to 0.3 nM for the IFN-α subtypes, and 0.03 nM and 0.07 nM for IFN-β and IFN-ω, respectively[2].
    Anifrolumab (67.7 nM) dose-dependently inhibits IFN-α production from pDCs in response to CpG-A or DNA-IC stimulation, inhibiting 87-95% of IFN-α production[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Anifrolumab 関連抗体

    Western Blot Analysis[2]

    Cell Line: Peripheral blood mononuclear cells (PBMCs)
    Concentration: 67.7 nM
    Incubation Time: 20 min
    Result: Abrogated IFN-α2-dependent and pDC supernatant-dependent STAT1 phosphorylation.

    Cell Differentiation Assay[2]

    Cell Line: Plasmacytoid dendritic cell (pDC)
    Concentration: 1 and 10 μg/mL
    Incubation Time: 6 or 7 days
    Result: Inhibited pDC-mediated plasma cell differentiation in a dose-dependent manner, with a mean 76% reduction in plasma cell number relative to control antibody.
    臨床実験
    Gene ID

    3454  [NCBI]

    Accession
    Application

    ELISA, FACS, Functional assay
    Conjugated

    Unconjugated
    Reconsititution

    The product can be reconstituted/diluted with sterile PBS or saline.
    分子量

    144.92 kDa

    CAS 番号
    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    [Anifrolumab]
    輸送条件

    Shipping with dry ice.
    Formulation

    Please refer to the lot-specific COA for specific buffer information.
    保管条件

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Format
    • Human IgG1 kappa
    Biological Activity
    • Immobilized IFNAR1 Protein, Human (HEK293, His, HY-P70483) can bind Anifrolumab. The EC50 for this effect is 21.2 ng/mL.
    • Flow cytometric analysis of 1.5X106 U937 cells with Anifrolumab (HY-P99168, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control.
    純度とドキュメンテーション

    純度: 99.79%

    COA (232 KB) SDS-PAGE (66 KB) SEC-HPLC (122 KB)

    Inhibitory Antibodies User Guide (603 KB)
    参考文献
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Anifrolumab Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Anifrolumab1326232-46-5MDX-1333 MEDI-546MDX1333MDX 1333MEDI546MEDI 546MEDI-546IFNARInterferon-α/β receptorInterferon-alpha/beta receptorsystemic lupus erythematosusSLEperipheral blood mononuclear cellsPBMCsplasmacytoid dendritic cellpDCInhibitorinhibitorinhibit

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    製品名:
    Anifrolumab
    製品番号:
    HY-P99168
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