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  3. Phospho-JAK2 (Tyr1007/1008) Antibody

Phospho-JAK2 (Tyr1007/1008) Antibody

Cat. No.: HY-P80829
COA User Guide for Antibodies

Phospho-JAK2 (Tyr1007/1008) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 131 kDa, targeting to Phospho-JAK2 (Tyr1007/1008). It can be used for WB,IHC-P,ICC/IF,IP,FC assays with tag free, in the background of Human, Mouse, Rat.

For research use only. We do not sell to patients.

Size Price Stock Quantity
Free Sample   Apply now  
10 μL $70 In-stock
50 μL $185 In-stock
100 μL $300 In-stock
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Description

Phospho-JAK2 (Tyr1007/1008) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 131 kDa, targeting to Phospho-JAK2 (Tyr1007/1008). It can be used for WB,IHC-P,ICC/IF,IP,FC assays with tag free, in the background of Human, Mouse, Rat.

Background

JAK2: This gene encodes a non-receptor tyrosine kinase that plays a central role in cytokine and growth factor signalling. The primary isoform of this protein has an N-terminal FERM domain that is required for erythropoietin receptor association, an SH2 domain that binds STAT transcription factors, a pseudokinase domain and a C-terminal tyrosine kinase domain. Cytokine binding induces autophosphorylation and activation of this kinase. This kinase then recruits and phosphorylates signal transducer and activator of transcription (STAT) proteins. Growth factors like TGF-beta 1 also induce phosphorylation and activation of this kinase and translocation of downstream STAT proteins to the nucleus where they influence gene transcription. Mutations in this gene are associated with numerous inflammatory diseases and malignancies. This gene is a downstream target of the pleiotropic cytokine IL6 that is produced by B cells, T cells, dendritic cells and macrophages to produce an immune response or inflammation. Disregulation of the IL6/JAK2/STAT3 signalling pathways produces increased cellular proliferation and myeloproliferative neoplasms of hematopoietic stem cells. A nonsynonymous mutation in the pseudokinase domain of this gene disrupts the domains inhibitory effect and results in constitutive tyrosine phosphorylation activity and hypersensitivity to cytokine signalling. This gene and the IL6/JAK2/STAT3 signalling pathway is a therapeutic target for the treatment of excessive inflammatory responses to viral infections. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2020]

Tag

Free

Gene ID

3717

Synonyms
JAK2; Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2
Molecular Weight

Predicted band size: 131 kDa

Purity

affinity purified

Conjugation

Non-conjugated

Research Field

Cell Biology

Product Categories

Primary Antibody; Rabbit Polyclonal Antibody

Host

Rabbit

Reactivity

Human, Mouse, Rat

SwissProt ID

O60674

Dilution Ratio

WB: 1:500-1:1,000 ;IHC: 1:50-1:100 ;IF: 1:50-1:200 ;IP: 1:20 ;FC: 1:50-1:100

Application

WB, IHC-P, ICC/IF, IP, FC

Appearance

Liquid

Formulation

Supplied in phosphate buffered saline (pH 7.4), 150 mM NaCl and 50% glycerol. Preservative: 0.02% sodium azide

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Isotype

IgG

Immunogen

Synthetic phosphopeptide corresponding to residues surrounding Tyr1007/1008 of Human Phospho-JAK2.The exact sequence is proprietary to MCE.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Phospho-JAK2 (Tyr1007/1008) Antibody
Cat. No.:
HY-P80829
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