JAK1 - Janus kinase 1 Gene

Also Known as JTK3; AIIDE; JAK1A; JAK1B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3716

About JAK1

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:64,833,229-65,067,746 (from NCBI)

This gene has 31 transcripts (splice variants), 238 orthologues, 32 paralogues and is associated with 113 phenotypes. Ubiquitous expression in lymph node (RPKM 51.3), fat (RPKM 49.8) and 25 other tissues.

Summary

This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic Cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2020]

JAK1 Products (12)

mRNA	Protein	Name
NM_002227.4	NP_002218.2	tyrosine-protein kinase JAK1 isoform 1
NM_001321853.2	NP_001308782.1	tyrosine-protein kinase JAK1 isoform 1
NM_001321852.2	NP_001308781.1	tyrosine-protein kinase JAK1 isoform 1
NM_001321854.2	NP_001308783.1	tyrosine-protein kinase JAK1 isoform 1
XM_047419674.1	XP_047275630.1	tyrosine-protein kinase JAK1 isoform X1
XM_047419676.1	XP_047275632.1	tyrosine-protein kinase JAK1 isoform X2
XM_047419675.1	XP_047275631.1	tyrosine-protein kinase JAK1 isoform X1
NM_001321856.2	NP_001308785.1	tyrosine-protein kinase JAK1 isoform 1
XM_047419677.1	XP_047275633.1	tyrosine-protein kinase JAK1 isoform X2
NM_001321855.2	NP_001308784.1	tyrosine-protein kinase JAK1 isoform 1
NM_001321857.2	NP_001308786.1	tyrosine-protein kinase JAK1 isoform 2
NM_001320923.2	NP_001307852.1	tyrosine-protein kinase JAK1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables non-membrane spanning protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	7657660	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7759950	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	11909529	GOA
enables protein tyrosine kinase activity	EXP EXP: Inferred from Experiment	1386289	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	7532278	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	24882218	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell surface receptor signaling pathway via JAK-STAT	IDA IDA: Inferred from direct assay	7657660	GOA
involved in cell surface receptor signaling pathway via JAK-STAT	IMP IMP: Inferred from mutant phenotype	28111307	GOA
involved in interleukin-10-mediated signaling pathway	IDA IDA: Inferred from direct assay	7543512	GOA
involved in interleukin-11-mediated signaling pathway	IDA IDA: Inferred from direct assay	8272872	GOA
involved in interleukin-15-mediated signaling pathway	IDA IDA: Inferred from direct assay	7568001	GOA
involved in interleukin-2-mediated signaling pathway	IDA IDA: Inferred from direct assay	7973659	GOA
involved in interleukin-4-mediated signaling pathway	IDA IDA: Inferred from direct assay	7929391	GOA
involved in interleukin-6-mediated signaling pathway	IDA IDA: Inferred from direct assay	8272873	GOA
involved in interleukin-9-mediated signaling pathway	IDA IDA: Inferred from direct assay	8756628	GOA
involved in positive regulation of homotypic cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	21679692	GOA
involved in positive regulation of protein localization to nucleus	IDA IDA: Inferred from direct assay	26479788	GOA
involved in positive regulation of sprouting angiogenesis	IGI IGI: Inferred from genetic interaction	20299512	GOA
involved in protein localization to cell-cell junction	IMP IMP: Inferred from mutant phenotype	21679692	GOA
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	28111307	GOA
acts upstream of or within response to antibiotic	IDA IDA: Inferred from direct assay	16280321	GOA
involved in type I interferon-mediated signaling pathway	IDA IDA: Inferred from direct assay	7532278	GOA
involved in type II interferon-mediated signaling pathway	IDA IDA: Inferred from direct assay	8232552	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10502458	GOA
is active in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	8272873	GOA
is active in extrinsic component of cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	7973659	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10502458	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

JAK1 Protein Structure

Pkinase_Tyr

0
200
400
600
800
1000
1154 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein kinase JAK1

JAK1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	JAK1	P23458	STAT1	Homo sapiens	P42224	Anti Tag CoIP	32953130
Intra	JAK1	P23458	JAK2	Homo sapiens	O60674	Confocal	26175413
Intra	JAK1	P23458	JAK2	Homo sapiens	O60674	Anti Bait CoIP	26175413
Intra	JAK1	P23458	STAT3	Homo sapiens	P40763	Anti Tag CoIP	31462771
Intra	JAK1	P23458	IFNAR2	Homo sapiens	P48551	Anti Bait CoIP	16710296

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant JAK1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78739	JAK1 Protein, Human (Inactive, sf9, His)	P23458 (A561-N852)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700583	JAK1 Protein, Human (P. pastoris, His)	P23458 (E850-K1154)	≥ 90%, as determined by reducing SDS-PAGE.

JAK1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80196	JAK1 Antibody (YA331)	WB, IHC-P, FC	Human, Mouse, Rat
HY-P80726	JAK1 Antibody (YA722)	WB, ICC/IF, IP	Human, Rat
HY-P80726A	JAK1 Antibody (YA722)(PBS only)	WB, ICC/IF, IP	Human, Rat
HY-P80829A	Phospho-JAK2 (Tyr1007/1008) Antibody (YA6449)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Myeloproliferative Neoplasm	Myeloproliferative Disorder Chronic Myeloproliferative Disease Myeloproliferative Neoplasms Chronic Myeloproliferative Disorder Cmpd Cmpd, U Chronic Myeloproliferative Disorders Mpd Mpn Myeloproliferative Disorders Myeloproliferative Disease Campomelic Dysplasia
Nasopharyngitis	Chronic Nasopharyngitis Chronic Rhinopharyngitis
Immunodeficiency 35	Tyrosine Kinase 2 Deficiency IMD35 Tyk2 Deficiency Autosomal Recessive Hyper-Ige Syndrome With Atypical Mycobacteriosis Susceptibility To Infection Due To Tyk2 Deficiency Hyper-Ige Syndrome With Atypical Mycobacteriosis, Autosomal Recessive Hies With Atypical Mycobacteriosis, Autosomal Recessive Autosomal Recessiv Hies With Atypical Mycobacteriosis Autosomal Recessive Hyper-Ige Syndrome Due To Tyk2 Deficiency Autosomal Recessive Hies With Atypical Mycobacteriosis
Autoinflammation, Immune Dysregulation, And Eosinophilia	AIIDE Atopic Dermatitis, Enteritis, Colitis, And Eosinophilia
Mixed Lacrimal Gland Cancer	Carcinoma Ex Pleomorphic Adenoma Of Lacrimal Gland Carcinoma Ex Pleomorphic Adenoma Of The Lacrimal Gland Malignant Mixed Neoplasm Of Lacrimal Gland
Autoimmune Disease Of Skin And Connective Tissue
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Central Nervous System Vasculitis	Vasculitis, Central Nervous System
Bone Marrow Cancer	Malignant Neoplasm Of Bone Marrow Bone Marrow Neoplasm Bone Marrow Tumor Malignant Bone Marrow Tumor Myeloproliferative Disorders Bone Marrow Neoplasms Myeloproliferative Disease Chronic Myeloproliferative Disorder
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Herpes Zoster	Shingles Zoster Herpes Zona Herpes Zoster Disease Zona Zoster Herpes Zoster Of Skin And Mucous Membranes Zoster Nos Zoster With Nervous System Involvement
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
T-Cell Prolymphocytic Leukemia	T Cell Prolymphocytic Leukemia Prolymphocytic Leukemia, T-Cell Type T-Pll T-Cell Chronic Lymphocytic Leukemia Lymphocytic Leukemia T-Cell Chronic Doid:0081042 Leukemia, T-Cell, Chronic Prolymphocytic Leukaemia Of T-Cell Type Without Mention Of Remission
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Hemophagocytic Lymphohistiocytosis	Lymphohistiocytosis, Hemophagocytic Haemophagocytic Syndrome Lymphohistiocytosis Hemophagocytic Hemophagocytic Syndrome Familial Hemophagocytic Lymphocytosis Histiocytoses Of Mononuclear Phagocytes Haemophagocytic Lymphohistiocytosis Nos
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Leukemia, Acute, X-Linked
Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Jak1 Deficiency	Autosomal Recessive Msmd Due To Partial Jak1 Deficiency
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Chronic Mucocutaneous Candidiasis	Candidiasis, Chronic Mucocutaneous Cmc Candidiasis Chronic Mucocutaneous
Polycythemia	Erythrocythemia Polycythemia Vera Polycythaemia Due To High Altitude
Severe Combined Immunodeficiency, X-Linked	X-Linked Severe Combined Immunodeficiency SCIDX1 XSCID Scidx X-Linked Scid X-Scid Severe Combined Immunodeficiency, X-Linked, T Cell-Negative, B Cell-Positive, Nk Cell-Negative Scid, X-Linked Immunodeficiency 4 Imd4 Gamma Chain Deficiency Scid-X1 X-Linked Combined Immunodeficiency Diseases Thymic Epithelial Hypoplasia Severe Combined Immunodeficiency T- B+ Due To Gamma Chain Deficiency Severe Combined Immunodeficiency T- B+, X-Linked Il2rg Scid, T- B+ Nk- T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency T-B+ Scid Due To Gamma Chain Deficiency T-B+ Severe Combined Immunodeficiency, X-Linked Severe Combined Immunodeficiency X-Linked T-Cell-Negative/B-Cell-Positive/Nk-Cell-Negative Agammaglobulinemia Swiss Type Scid X-Linked Severe Combined Immunodeficiency X-Linked T Cell-Negative/B Cell-Positive/Nk Cell-Negative Severe Combined Immunodeficiency X-Linked T-Cell Negative/B-Cell Positive/Nk-Cell Negative Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Acute Megakaryoblastic Leukemia In Down Syndrome	Ds-Amkl
Autoimmune Lymphoproliferative Syndrome	ALPS Canale-Smith Syndrome Autoimmune Lymphoproliferative Syndrome, Type Ia Autoimmune Lymphoproliferative Syndrome, Type Ib Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant Css Autoimmune Lymphoproliferative Syndrome, Type 1b Autoimmune Lymphoproliferative Syndrome, Type 1a Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant Fas Deficiency Autoimmune Lymphoproliferative Syndrome 1a ALPS1A Autoimmune Lymphoproliferative Syndrome Type Ia Autoimmune Lymphoproliferative Syndrome 1b ALPS1B Autoimmune Lymphoproliferative Syndrome Type Ib
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Hypereosinophilic Syndrome	Eosinophilia HES Eosinophilic Leukocytosis Hypereosinophilic Syndrome, Idiopathic Idiopathic Hypereosinophilic Syndrome Disseminated Eosinophilic Collagen Disease Eosinophilic Disorder Disorders With Increased Eosinophil Counts
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Encephalopathy With Basal Ganglia Calcification Aicardi-Goutières Syndrome Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1
Alopecia Universalis Congenita	Alopecia Universalis ALUNC Atrichia, Generalized Au Alopecia Areata Universalis Atrichia Generalized
Myelofibrosis	Primary Myelofibrosis Agnogenic Myeloid Metaplasia Idiopathic Myelofibrosis Myeloid Metaplasia Myelofibrosis With Myeloid Metaplasia Osteomyelofibrosis Megakaryocytic Myelosclerosis Myelosclerosis Chronic Idiopathic Myelofibrosis Myelofibrosis, Idiopathic Myelofibrosis With Myeloid Metaplasia, Somatic Myelofibrosis, Somatic Aleukemic Myelosis Bone Marrow Fibrosis MYELOF MMM Agnogenic Myeloid Metaplasia With Myelofibrosis Ammm Myelosclerosis With Myeloid Metaplasia Myelofibrosis Nos
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Immunodeficiency 27a	IMD27A Autosomal Recessive Ifngr1 Deficiency Autosomal Recessive Immunodeficiency 27a, Mycobacteriosis Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency Autosomal Recessive Msmd Due To Partial Ifngammar1 Deficiency Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency Immunodeficiency 27a, Mycobacteriosis, Autosomal Recessive Ifngr1 Deficiency, Autosomal Recessive Immunodeficiency 27a, Mycobacteriosis, Ar Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar1 Deficiency Msmd Due To Complete Ifngammar1 Deficiency Msmd Due To Complete Interferon Gamma Receptor 1 Deficiency Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 1 Deficiency Familial Disseminated Atypical Mycobacterial Infection Interferon Gamma, Receptor 1, Deficiency Immunodeficiency, Type 27a, Mycobacteriosis, Ar Mycobacterial Disease, Mendelian Susceptibility To
Skin Disease	Skin Diseases Abnormality Of The Skin Skin Diseases, Genetic Genodermatosis Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Sezary'S Disease	Sezary Syndrome Sézary Syndrome Sezary'S Lymphoma Sezary Disease Sezary Erythroderma Sezary Lymphoma
Autoimmune Disease Of Musculoskeletal System
Fallopian Tube Clear Cell Adenocarcinoma	Clear Cell Carcinoma Of The Fallopian Tube
Plasmablastic Lymphoma	Pbl Immunoblastic Large-Cell Lymphoma
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Disease Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Intellectual Developmental Disorder, Autosomal Dominant 4	MRD4 Autosomal Dominant Non-Syndromic Intellectual Disability 4 Mental Retardation, Autosomal Dominant 4 Autosomal Dominant Intellectual Developmental Disorder 4
Lymphoblastic Leukemia, Acute, With Lymphomatous Features	LALL Lymphomatous All Leukemia, Acute Lymphoblastic Acute Lymphoblastic Leukemia With Lymphomatous Features
Chilblain Lupus 1	Chilblain Lupus CHBL1 Chilblain Lupus Erythematosus Chle Hutchinson Lupus Chilblain Lupus, Type 1
Fibrosarcoma	Neoplasms, Fibrous Tissue Fibrocytic Tumor Fibrosarcoma Of Soft Tissue Fibrous Tissue Neoplasm
Hyper Ige Syndrome	Hyper-Ige Syndrome Hyper Immunoglobulin E Syndrome Hies Hyper-Ige Recurrent Infection Syndrome Hyperimmunoglobulin E Syndrome Hyper Ige Job Syndrome Hartnup Disease
Dermatitis	Eczema Skin Inflammation Inflammatory Dermatosis
Psoriasis
Measles	Rubeola Morbilli Measles Nos Koplik Spots
Lymphoproliferative Syndrome	Lymphoproliferative Disorder Lymphoproliferative Disorders Lymphoproliferative Disorders, Susceptibility To
Essential Thrombocythemia	Essential Thrombocytosis Familial Thrombocytosis Hemorrhagic Thrombocythemia Hereditary Thrombocythemia Primary Thrombocytosis Idiopathic Thrombocythemia Primary Thrombocythemia Thrombocythemia, Essential Essential Thrombocythaemia Et Familial Thrombocythemia Thrombocythemia Essential
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Blood Platelet Disease	Platelet Disorder Blood Platelet Disorders Thrombocytopathy Platelet Dysfunction Platelet Disorders Qualitative Platelet Deficiency
Polycythemia Vera	PV Polycythemia Rubra Vera Prv Osler-Vaquez Disease Chronic Erythremia Polycythaemia Rubra Vera Primary Polycythemia Vaquez Disease Polycythemia Vera, Somatic Osler-Vaquez Syndrome Proliferative Polycythaemia Polycythemia Ruba Vera Acquired Primary Erythrocytosis Heilmeyer-Schoner Disease Vaquez Osler Disease Primary Polycythaemia
Wernicke Encephalopathy	Wernicke'S Encephalopathy Wernicke'S Disease Encephalopathy, Wernicke'S Wernicke-Korsakoff Syndrome Encephalopathy Due To Vitamin B1 Deficiency Wernicke Disease Wernicke Syndrome
Psoriatic Arthritis	Psoriatic Arthritis, Susceptibility To Psoriatic Arthropathy Arthropathic Psoriasis Arthritis, Psoriatic Arthritis Psoriatica PSORAS Arthritic Psoriasis Psoriasis Arthropathica Arthritis Psoriatic Arthritis, Psoriatic, Susceptibility To
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Temporal Arteritis	Polymyalgia Rheumatica Giant Cell Arteritis Cranial Arteritis Horton Disease Gca Horton'S Disease Rhizomelic Pseudopolyarthritis Arteritis Cranialis Arteritis Temporalis Horton'S Arteritis Horton'S Giant Cell Arteritis Horton'S Temporal Arteritis Horton'S Syndrome Gca - [Giant Cell Arteritis] Senile Arthritis Polymyalgia Arteritica Pmr - [Polymyalgia Rheumatica] Forestier-Certonciny Syndrome Rheumatic Polymyalgia Polymyalgia
Breast Implant-Associated Anaplastic Large Cell Lymphoma
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Hepatitis C	Chronic Hepatitis C Hepatitis C Infection Hepatitis Nona Nonb Nanbh Viral Hepatitis C Hepatitis C Chronic Hepatitis C, Chronic Chronic Type C Viral Hepatitis Chronic Hcv - [Hepatitis C Virus] Infection Hepatitis C Nos Hepatitis C Infection Nos Hepatitis C-Related Cirrhosis Type C Viral Hepatitis Hep C Nos
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Sting-Associated Vasculopathy With Onset In Infancy	Savi Sting-Associated Vasculopathy, Infantile Onset Sting-Associated Vasculopathy, Infantile-Onset

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-50856	Ruxolitinib	Inhibitor	99.99%	Yes
HY-40354	Tofacitinib	Inhibitor	99.99%	Yes
HY-19569	Upadacitinib	Inhibitor	99.98%	Yes
HY-15315	Baricitinib	Inhibitor	99.97%	Yes
HY-117287	Deucravacitinib	Inhibitor	99.93%	Unkown
HY-50858	Ruxolitinib phosphate	Inhibitor	99.92%	Yes
HY-40354A	Tofacitinib citrate	Inhibitor	99.94%	Yes
HY-16379	Pacritinib	Inhibitor	99.93%	Yes
HY-10961	Momelotinib	Inhibitor	98.93%	Unkown
HY-107429	Abrocitinib	Inhibitor	99.26%	Unkown
HY-18300	Filgotinib	Inhibitor	99.77%	Yes
HY-19568	Peficitinib	Inhibitor	99.43%	Yes
HY-15315A	Baricitinib phosphate	Inhibitor	99.97%	Yes
HY-109053	Delgocitinib	Inhibitor	99.61%	Unkown
HY-13577	Oclacitinib	Inhibitor	99.03%	Unkown
HY-13577A	Oclacitinib monomaleate	Inhibitor	99.87%	Unkown
HY-50856S	Deuruxolitinib	Inhibitor	99.18%	Unkown
HY-18300A	Filgotinib maleate	Inhibitor	99.88%	Yes
HY-50859	Ruxolitinib sulfate	Inhibitor	/	Unkown
HY-19568A	Peficitinib hydrobromide	Inhibitor	/	Unkown
HY-19569A	Upadacitinib tartrate tetrahydrate	Inhibitor	/	Unkown
HY-16379A	Pacritinib hydrochloride	Inhibitor	/	Unkown
HY-19568B	Peficitinib hydrochloride	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112724	Ivarmacitinib	Inhibitor	99.62%	Phase 4
HY-16997	Itacitinib	Inhibitor	99.97%	Phase 3
HY-107361	Golidocitinib	Inhibitor	99.54%	Phase 3
HY-15999	Cerdulatinib	Inhibitor	99.06%	Phase 3
HY-12469	Decernotinib	Inhibitor	99.91%	Phase 3
HY-112708A	Brepocitinib P-Tosylate	Inhibitor	99.99%	Phase 3
HY-174905	Quecitinib	Inhibitor	99.56%	Phase 3
HY-130247A	Flonoltinib TFA	Inhibitor	98.94%	Phase 3
HY-10193	AZD-1480	Inhibitor	99.74%	Phase 2
HY-126294	Londamocitinib	Inhibitor	99.79%	Phase 2
HY-15270	BMS-911543	Inhibitor	98.23%	Phase 2
HY-156961	Cadefrecitinib	Inhibitor	99.81%	Phase 2
HY-16755	Solcitinib	Inhibitor	99.51%	Phase 2
HY-19631	Ilginatinib maleate	Inhibitor	99.33%	Phase 2
HY-159536	Frevecitinib	Inhibitor	99.42%	Phase 2
HY-101024	PF-06263276	Inhibitor	≥99.0%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99244	Fezakinumab	Modulator	99.9%	Phase 2

Pre-clinical Phase

Bioactive Molecules (94)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W063968	RO8191	Activator	≥99.0%	Unkown
HY-112708	Brepocitinib	Inhibitor	99.95%	Yes
HY-14435	Pyridone 6	Inhibitor	98.20%	Unkown
HY-130247	Flonoltinib	Inhibitor	99.48%	Unkown
HY-145551	Atinvicitinib	Inhibitor	98.62%	Unkown
HY-10962	Momelotinib sulfate	Inhibitor	98.63%	Yes
HY-151385	VVD-118313	Inhibitor	99.47%	Unkown
HY-14722	NVP-BSK805	Inhibitor	99.30%	Unkown
HY-19631A	Ilginatinib	Inhibitor	99.81%	Unkown
HY-100895	SAR-20347	Inhibitor	97.27%	Unkown
HY-108264	TCS 21311	Inhibitor	99.49%	Unkown
HY-162608	PROTAC JAK1 degrader 1	Degrader	99.97%	Unkown
HY-151262	JAK-IN-23	Inhibitor	98.88%	Unkown
HY-12589	ZM39923 hydrochloride	Inhibitor	99.84%	Unkown
HY-12538	Graveoline	Inhibitor	99.93%	Unkown
HY-15814	HG-7-85-01	Inhibitor	98.14%	Unkown
HY-153701S	Envudeucitinibum	Inhibitor	99.56%	Unkown
HY-14722A	NVP-BSK805 dihydrochloride	Inhibitor	99.36%	Unkown
HY-19544	JAK3-IN-1	Inhibitor	99.31%	Unkown
HY-15999A	Cerdulatinib hydrochloride	Inhibitor	98.96%	Yes
HY-131906	JAK2-IN-7	Inhibitor	98.31%	Unkown
HY-150720	TYK2-IN-12	Inhibitor	98.81%	Unkown
HY-19631B	Ilginatinib hydrochloride	Inhibitor	98.92%	Unkown
HY-W394903	GS-829845	Inhibitor	99.19%	Unkown
HY-139423	JAK1-IN-8	Inhibitor	95.0%	Unkown
HY-162248	JAK1/2-IN-1	Inhibitor	98.36%	Unkown
HY-143444	JAK-IN-20	Inhibitor	99.63%	Unkown
HY-120469	2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide	Inhibitor	99.80%	Unkown
HY-151385A	(R,R)-VVD-118313	Inhibitor	99.34%	Unkown
HY-179715	PROTAC JAK1/2 degrader-1	Degrader	99.47%	Unkown
HY-153440	Methyl 6-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate	Inhibitor	98.01%	Unkown
HY-111750	JAK-IN-3	Inhibitor	98.92%	Unkown
HY-N7653	Azaleatin	Inhibitor	98.86%	Unkown
HY-13961	GLPG0634 analog	Inhibitor	98.07%	Unkown
HY-126141	JAK/HDAC-IN-1	Inhibitor	98.63%	Unkown
HY-100849	JAK 3i	Inhibitor	99.81%	Unkown
HY-152080	Blovacitinib	Inhibitor	99.71%	Unkown
HY-179716	JAK1/2 ligand 1	Ligand	99.91%	Unkown
HY-116505	JAK1-IN-4	Inhibitor	99.26%	Unkown
HY-13450	ZM 449829	Inhibitor	99.73%	Unkown
HY-16997A	Itacitinib adipate	Inhibitor	99.18%	Yes
HY-148060	JAK-IN-21	Inhibitor	99.72%	Unkown
HY-161618	MJ04	Inhibitor	98.08%	Unkown
HY-170772	Dual Cathepsin L/JAK-IN-1	Inhibitor	98.47%	Unkown
HY-123115	Leucrose		98.53%	Unkown
HY-181929	RAI-20	Inhibitor	98.66%	Unkown
HY-182359	YYSW001	Inhibitor	/	Unkown
HY-14722C	NVP-BSK805 trihydrochloride	Inhibitor	/	Unkown
HY-168893	K882	Inhibitor	/	Unkown
HY-170977	JAK1/STAT3-IN-1	Inhibitor	/	Unkown
HY-W635076	oJak-989	Inhibitor	/	Unkown
HY-149296	JAK1-IN-12	Inhibitor	/	Unkown
HY-108342	PF-00956980	Inhibitor	/	Unkown
HY-161259	JAK-IN-36	Inhibitor	/	Unkown
HY-146727	JAK3-IN-11	Inhibitor	/	Unkown
HY-153566	JAK1-IN-10	Inhibitor	/	Unkown
HY-W064657	Momelotinib dihydrochloride	Inhibitor	99.56%	Unkown
HY-177006	JAK1/2-IN-2	Inhibitor	/	Unkown
HY-164111	JNK-IN-17	Inhibitor	/	Unkown
HY-180274	JAK1/2-IN-3	Inhibitor	/	Unkown
HY-149283	JAK/HDAC-IN-2	Inhibitor	/	Unkown
HY-181872	JAK1-IN-20	Inhibitor	/	Unkown
HY-174999	JAK3-IN-18	Inhibitor	/	Unkown
HY-181528	JAK1/CDK7-IN-1	Inhibitor	/	Unkown
HY-176793	JAK1-IN-18	Inhibitor	/	Unkown
HY-161139	JAK1-IN-14	Inhibitor	/	Unkown
HY-168269	Tyk2-IN-20	Inhibitor	/	Unkown
HY-170723	JAK-IN-39	Inhibitor	/	Unkown
HY-147975	JAK3-IN-12	Inhibitor	/	Unkown
HY-154994	JAK-IN-30	Inhibitor	/	Unkown
HY-175684	JAK2-IN-14	Inhibitor	/	Unkown
HY-143885	JAK1/TYK2-IN-3	Inhibitor	/	Unkown
HY-168339	Tyk2-IN-22	Inhibitor	/	Unkown
HY-139649	Ten01	Inhibitor	/	Unkown
HY-184592	JAK1-IN-21	Inhibitor	/	Unkown
HY-152080A	(R)-Blovacitinib	Inhibitor	/	Unkown
HY-174430	WWQ-131	Inhibitor	/	Unkown
HY-147754	JAK3/BTK-IN-6	Inhibitor	/	Unkown
HY-178282	JAK1-IN-19	Inhibitor	/	Unkown
HY-144440	JAK1-IN-9	Inhibitor	/	Unkown
HY-N14094	Tubulosine	Inhibitor	/	Unkown
HY-187502	Jak1 RIMTAC-1	Degrader	/	Unkown
HY-175983	JAK1/TYK2-IN-5	Inhibitor	/	Unkown
HY-175009	MRC-G-001	Inhibitor	/	Unkown
HY-162862	JAK-IN-38	Inducer	/	Unkown
HY-130247B	Flonoltinib monomaleate	Inhibitor	/	Unkown
HY-12589A	ZM39923	Inhibitor	/	Unkown
HY-162862	JAK-IN-38	Inhibitor	/	Unkown
HY-10963	Momelotinib mesylate	Inhibitor	/	Unkown
HY-185924	Domusiran	Inhibitor	/	Unkown
HY-183519	AH057	Inhibitor	/	Unkown
HY-157121	JAK-IN-34	Inhibitor	/	Unkown
HY-123939	JAK1/3-IN-1	Inhibitor	/	Unkown
HY-123187	AS2553627	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	JAK1	VGNC	VGNC:67876
Canis familiaris	JAK1	VGNC	VGNC:42175
Macaca mulatta	JAK1	VGNC	VGNC:73810
Rattus norvegicus	JAK1	RGD	RGD:69056
Bos taurus	JAK1	VGNC	VGNC:30364
Mus musculus	JAK1	MGD	MGI:96628
Others	JAK1	NCBI