1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK
  3. ZM 449829

ZM 449829 

Cat. No.: HY-13450
Handling Instructions

ZM 449829 is a potent, selective and ATP competitive inhibitor of JAK3, with a pIC50 of 6.8. ZM 449829 will be useful pharmacological tools for the investigation of the JAK3.

For research use only. We do not sell to patients.

ZM 449829 Chemical Structure

ZM 449829 Chemical Structure

CAS No. : 4452-06-6

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Description

ZM 449829 is a potent, selective and ATP competitive inhibitor of JAK3, with a pIC50 of 6.8. ZM 449829 will be useful pharmacological tools for the investigation of the JAK3[1].

IC50 & Target[1]

JAK3

6.8 (pIC50)

In Vitro

ZM 449829 (compound 22) is a very weak inhibitors of EGF-R (pIC50=5.0) , Jak1 (pIC50=4.7), and tyrosine kinases Lck and CDK4 (pIC50 <5.0)[1].
ZM449829 (1 μM; 30 minutes) blocks IL-2-induced STAT5 phosphorylation[2].

Western Blot Analysis[2]

Cell Line: YTS, NK92, and ex vivo NK cells
Concentration: 1 μM
Incubation Time: 30 minutes pretreatment
Result: Inhibits the phosphorylation of STAT5.
Molecular Weight

182.22

Formula

C₁₃H₁₀O

CAS No.

4452-06-6

SMILES

C=CC(C1=CC=C2C=CC=CC2=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

ZM 449829ZM449829ZM-449829JAKJanus kinaseInhibitorinhibitorinhibit

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ZM 449829
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