1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK

JAK1-IN-4 

Cat. No.: HY-116505
Handling Instructions

JAK1-IN-4 is a potent and selective JAK1 inhibitor, with IC50s of 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively. JAK1-IN-4 inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50, 227 nM).

For research use only. We do not sell to patients.

JAK1-IN-4 Chemical Structure

JAK1-IN-4 Chemical Structure

CAS No. : 2091134-35-7

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Description

JAK1-IN-4 is a potent and selective JAK1 inhibitor, with IC50s of 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively. JAK1-IN-4 inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50, 227 nM)[1].

IC50 & Target[1]

JAK1

85 nM (IC50)

JAK2

12.8 μM (IC50)

References
Molecular Weight

521.59

Formula

C₂₆H₃₂FN₉O₂

CAS No.

2091134-35-7

SMILES

O=C(NC1=CC=CC2=C1NC=C2C3=C(C=NC(NC4=CN(N=C4OC)C)=N3)F)[[email protected]](N5CCN([[email protected]@H](C5)C)C)C

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
JAK1-IN-4
Cat. No.:
HY-116505
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JAK1-IN-4

Cat. No.: HY-116505