2091134-35-7
2091134-35-7
Chemical Structure
JAK1-IN-4
- CAS No.: 2091134-35-7
- Formula:C26H32FN9O2
- Molecular Weight:521.59
IUPAC Name: (R)-2-((R)-3,4-dimethylpiperazin-1-yl)-N-(3-(5-fluoro-2-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-1H-indol-7-yl)propanamide
InChIKey: HKMXSVZYKLTDAP-HZPDHXFCSA-N
SMILES: O=C(NC1=CC=CC2=C1NC=C2C3=C(C=NC(NC4=CN(N=C4OC)C)=N3)F)[C@H](N5CCN([C@@H](C5)C)C)C
Biological Activity: JAK1-IN-4 is a potent and selective JAK1 inhibitor, with IC50s of 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively. JAK1-IN-4 inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50, 227 nM)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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JAK1-IN-4 | 99.26% | JAK1-IN-4 is a potent and selective JAK1 inhibitor, with IC50s of 85 nM, 12.8 μM and >30 μM for JAK1, JAK2, and JAK3, respectively. JAK1-IN-4 inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50, 227 nM). | ||||||||||||||||||||
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References
Keywords
