JAK1/2-IN-1
Based on 1 Customer Validation
JAK1/2-IN-1 is a potent JAK1 and JAK2 inhibitor with IC50 values of 0.4 nM and 8.1 nM, respectively. JAK1/2-IN-1 also inhibits IL-4 and IL-13 with IC50s of 136.5 nM and 19.1 nM, respectively (WO2023244775A1; Example 33a).
For research use only. We do not sell to patients.
- Purity: 98.36%
- CAS No.: 3023876-01-6
- Formula: C19H19BF3N5O3
- Molecular Weight:433.19
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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JAK1 0.4 nM (IC50) |
JAK2 8.1 nM (IC50) |
IL-4 136.5 nM (IC50) |
IL-13 19.1 nM (IC50) |
Chemical Information
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CAS No. 3023876-01-6
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Appearance Solid
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Molecular Weight 433.19
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Formula C19H19BF3N5O3
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Color White to off-white
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SMILES
FC(F)(C1=C2C(COB2O)=CC(NC3=NC=C(C)C(N[C@@H]4[C@H](CCOC4)C#N)=N3)=C1)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (288.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3085 mL | 11.5423 mL | 23.0846 mL | 57.7114 mL |
| 5 mM | 0.4617 mL | 2.3085 mL | 4.6169 mL | 11.5423 mL | |
| 10 mM | 0.2308 mL | 1.1542 mL | 2.3085 mL | 5.7711 mL | |
| 15 mM | 0.1539 mL | 0.7695 mL | 1.5390 mL | 3.8474 mL | |
| 20 mM | 0.1154 mL | 0.5771 mL | 1.1542 mL | 2.8856 mL | |
| 25 mM | 0.0923 mL | 0.4617 mL | 0.9234 mL | 2.3085 mL | |
| 30 mM | 0.0769 mL | 0.3847 mL | 0.7695 mL | 1.9237 mL | |
| 40 mM | 0.0577 mL | 0.2886 mL | 0.5771 mL | 1.4428 mL | |
| 50 mM | 0.0462 mL | 0.2308 mL | 0.4617 mL | 1.1542 mL | |
| 60 mM | 0.0385 mL | 0.1924 mL | 0.3847 mL | 0.9619 mL | |
| 80 mM | 0.0289 mL | 0.1443 mL | 0.2886 mL | 0.7214 mL | |
| 100 mM | 0.0231 mL | 0.1154 mL | 0.2308 mL | 0.5771 mL |
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