3023876-01-6
3023876-01-6
Chemical Structure
JAK1/2-IN-1
- CAS No.: 3023876-01-6
- Formula:C19H19BF3N5O3
- Molecular Weight:433.19
InChIKey: ASDXEWKHPIPSQL-ABAIWWIYSA-N
SMILES: FC(F)(C1=C2C(COB2O)=CC(NC3=NC=C(C)C(N[C@@H]4[C@H](CCOC4)C#N)=N3)=C1)F
Biological Activity: JAK1/2-IN-1 is a potent JAK1 and JAK2 inhibitor with IC50 values of 0.4 nM and 8.1 nM, respectively. JAK1/2-IN-1 also inhibits IL-4 and IL-13 with IC50s of 136.5 nM and 19.1 nM, respectively (WO2023244775A1; Example 33a)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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JAK1/2-IN-1 | 98.36% | JAK1/2-IN-1 is a potent JAK1 and JAK2 inhibitor with IC50 values of 0.4 nM and 8.1 nM, respectively. JAK1/2-IN-1 also inhibits IL-4 and IL-13 with IC50s of 136.5 nM and 19.1 nM, respectively (WO2023244775A1; Example 33a). | ||||||||||||||||||||
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References
Keywords
