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oJak-989

oJak-989 is a selective JAK1 inhibitor with a K_i of 2.8 nM for JAK1, 110 nM for JAK3, and 31 nM for TYK2. oJak-989 is applicable to the research of inflammatory diseases.

For research use only. We do not sell to patients.

CAS No.: 1315485-91-6
Formula: C₁₅H₁₈N₄O₂
Molecular Weight:286.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

oJak-989 Chemical Structure

CAS No.: 1315485-91-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

oJak-989 is a selective JAK1 inhibitor with a K_i of 2.8 nM for JAK1, 110 nM for JAK3, and 31 nM for TYK2. oJak-989 is applicable to the research of inflammatory diseases^[1].

IC₅₀ & Target^[1]

JAK1

2.8 nM (Ki)

All JAK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
TF-1	EC₅₀	110 nM Compound: 21	Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-induced STAT3 phosphorylation incubated for 20 mins followed by IL6 challenge for 30 mins Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-induced STAT3 phosphorylation incubated for 20 mins followed by IL6 challenge for 30 mins	[PMID: 23659214]
TF-1	EC₅₀	180 nM Compound: 21	Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-induced STAT3 phosphorylation incubated for 20 mins followed by IL6 challenge for 30 mins in presence of whole blood Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-induced STAT3 phosphorylation incubated for 20 mins followed by IL6 challenge for 30 mins in presence of whole blood	[PMID: 23659214]

In Vitro

oJak-989 (Compound 21) is a potent and highly JAK1-selective inhibitor with a JAK1 K_i of 2.8 nM. It exhibits 26-fold selectivity over JAK2 in biochemical assays and 51-fold selectivity in cellular assays. Additionally, it possesses favorable MDCK permeability, low whole blood potency shift, high water solubility, and shows no significant hERG or clinically relevant CYP inhibition^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1315485-91-6
Molecular Weight 286.34
Formula C₁₅H₁₈N₄O₂
SMILES

[C@H](C)(O)C=1N(C2=C3C(NC=C2N1)=NC=C3)[C@H]4CCCOC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zak M, et al. Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2. J Med Chem. 2013;56(11):4764-4785. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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