JAK3-IN-12
JAK3-IN-12 (compound 5k) is a highly potent JAK3 inhibitor with IC50 values of 9.5 nM, 18 nM and 42 nM for JAK3, JAK1 and JAK2, respectively. JAK3-IN-12 can be used for researching rheumatoid arthritis.
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- CAS No.: 1430095-86-5
- Formule: C19H19N5O4S
- Masse moléculaire:413.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
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Activité biologique
Description
IC50 & Target
[1]|
JAK3 9.5 nM (IC50) |
JAK1 18 nM (IC50) |
JAK2 42 nM (IC50) |
In Vivo
Pharmacokinetic Parameters of JAK3-IN-12 in male C57BL/6J mice[1].
| Tmax (h) | Cmax (ng/ml) | tmax (h) | CL (mL/min/kg), iv | AUC0-α (μg/mL·h) | F (%) | |
| IV (1 mg/kg); PO (3 mg/kg) |
0.5 | 146±48 | 1.85±0.43 | 40.37 ± 3.61 | 192 ± 56 | 15 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL/6J mice[1]
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Dosage:1 mg/kg for IV; 3 mg/kg for PO
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Administration:IV or PO; single dosage
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Result:Showed moderate AUC, due to its high clearance, which resulted into overall low bioavailability (15%).
Chemical Information
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CAS No. 1430095-86-5
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Masse moléculaire 413.45
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Formule C19H19N5O4S
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SMILES
CS(=O)(OC1=CC=C(NC2=NC=C(C(N)=O)C(NCC3=CC=CC=C3)=N2)C=C1)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JAK3-IN-12 Related Classifications
HY-147975 Related Classifications
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