1. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  2. JAK
  3. JAK3-IN-12

JAK3-IN-12 

Cat. No.: HY-147975
Handling Instructions

JAK3-IN-12 (compound 5k) is a highly potent JAK3 inhibitor with IC50 values of 9.5 nM, 18 nM and 42 nM for JAK3, JAK1 and JAK2, respectively. JAK3-IN-12 can be used for researching rheumatoid arthritis.

For research use only. We do not sell to patients.

JAK3-IN-12 Chemical Structure

JAK3-IN-12 Chemical Structure

CAS No. : 1430095-86-5

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Description

JAK3-IN-12 (compound 5k) is a highly potent JAK3 inhibitor with IC50 values of 9.5 nM, 18 nM and 42 nM for JAK3, JAK1 and JAK2, respectively. JAK3-IN-12 can be used for researching rheumatoid arthritis[1].

IC50 & Target[1]

JAK3

9.5 nM (IC50)

JAK1

18 nM (IC50)

JAK2

42 nM (IC50)

In Vivo

JAK3-IN-12 (compound 5k) shows moderate AUC, due to its high clearance, which resulted into overall low bioavailability[1].
Pharmacokinetic Parameters of JAK3-IN-12 in male C57BL/6J mice[1].

Tmax (h) Cmax (ng/ml) tmax (h) CL (mL/min/kg), iv AUC0-α (μg/mL·h) F (%)
IV (1 mg/kg);
PO (3 mg/kg)
0.5 146±48 1.85±0.43 40.37 ± 3.61 192 ± 56 15

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice[1]
Dosage: 1 mg/kg for IV; 3 mg/kg for PO
Administration: IV or PO; single dosage
Result: Showed moderate AUC, due to its high clearance, which resulted into overall low bioavailability (15%).
Molecular Weight

413.45

Formula

C19H19N5O4S

CAS No.
SMILES

CS(=O)(OC1=CC=C(NC2=NC=C(C(N)=O)C(NCC3=CC=CC=C3)=N2)C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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JAK3-IN-12
Cat. No.:
HY-147975
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