1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK
  3. ZM39923

ZM39923 

Cat. No.: HY-12589A
Handling Instructions

ZM39923 is a JAK3 inhibitor, with a pIC50 of 7.1; ZM39923 also potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM.

For research use only. We do not sell to patients.

ZM39923 Chemical Structure

ZM39923 Chemical Structure

CAS No. : 273727-89-2

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Description

ZM39923 is a JAK3 inhibitor, with a pIC50 of 7.1; ZM39923 also potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM.

IC50 & Target[1][2]

JAK3

7.1 (pIC50)

JAK1

4.4 (pIC50)

EGF-R

5.6 (pIC50)

Lck

5.0 (pIC50)

CDK4

5.0 (pIC50)

TGM2

10 nM (IC50)

In Vitro

ZM39923 is a JAK3 inhibitor, with a pIC50 of 7.1. ZM39923 (Compound 7) shows weak inhibitory effect on EGF-R and JAK1 (pIC50, 5.6, 4.4, respectively), and insignificantly inhibits tyrosine kinases Lck and CDK4 (pIC50 <5.0)[1]. ZM39923 potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM, and acts directly on purified TGM2 to inhibit the Ca2+ activated form of TGM2[2]. ZM39923 blocks the phosphorylation of JAK3 induced by CCL19, and such an effect is similar to that of CCR7 antibody. ZM39923 also significantly blocks the CCL19 induced wound closure rate, and decreases the migration and invasion of PCI-37B cells[3].

Molecular Weight

331.45

Formula

C₂₃H₂₅NO

CAS No.

273727-89-2

SMILES

O=C(C1=CC=C2C=CC=CC2=C1)CCN(C(C)C)CC3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Cell Assay
[3]

PCI-37B (a metastatic SCCHN cell line expressing CCR7) cells are cultured in Dulbecco's modified Eagle's medium (DMEM) containing 10% fetal bovine serum, penicillin, and streptomycin in an atmosphere of 5% CO2 and 95% air at 37°C. The ZM39923 inhibitor treatment at the dose determined using the Cell Counting Kit-8[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

ZM39923ZM 39923ZM-39923JAKJanus kinaseInhibitorinhibitorinhibit

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ZM39923
Cat. No.:
HY-12589A
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