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  3. ZM39923 hydrochloride

ZM39923 hydrochloride 

Cat. No.: HY-12589 Purity: 99.86%
Handling Instructions

ZM39923 hydrochloride is a JAK3 inhibitor, with a pIC50 of 7.1; ZM39923 hydrochloride also potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM.

For research use only. We do not sell to patients.

ZM39923 hydrochloride Chemical Structure

ZM39923 hydrochloride Chemical Structure

CAS No. : 1021868-92-7

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Description

ZM39923 hydrochloride is a JAK3 inhibitor, with a pIC50 of 7.1; ZM39923 hydrochloride also potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM.

IC50 & Target[1][2]

JAK3

7.1 (pIC50)

JAK1

4.4 (pIC50)

EGF-R

5.6 (pIC50)

Lck

5.0 (pIC50)

CDK4

5.0 (pIC50)

TGM2

10 nM (IC50)

In Vitro

ZM39923 hydrochloride is a JAK3 inhibitor, with a pIC50 of 7.1. ZM39923 (Compound 7) shows weak inhibitory effect on EGF-R and JAK1 (pIC50, 5.6, 4.4, respectively), and insignificantly inhibits tyrosine kinases Lck and CDK4 (pIC50 <5.0)[1]. ZM39923 potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10 nM, and acts directly on purified TGM2 to inhibit the Ca2+ activated form of TGM2[2]. ZM39923 blocks the phosphorylation of JAK3 induced by CCL19, and such an effect is similar to that of CCR7 antibody. ZM39923 also significantly blocks the CCL19 induced wound closure rate, and decreases the migration and invasion of PCI-37B cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

367.91

Formula

C₂₃H₂₆ClNO

CAS No.

1021868-92-7

SMILES

O=C(C1=CC=C2C=CC=CC2=C1)CCN(C(C)C)CC3=CC=CC=C3.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 47 mg/mL (127.75 mM)

H2O : 1 mg/mL (2.72 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7181 mL 13.5903 mL 27.1806 mL
5 mM 0.5436 mL 2.7181 mL 5.4361 mL
10 mM 0.2718 mL 1.3590 mL 2.7181 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.80 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.80 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.80 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Cell Assay
[3]

PCI-37B (a metastatic SCCHN cell line expressing CCR7) cells are cultured in Dulbecco's modified Eagle's medium (DMEM) containing 10% fetal bovine serum, penicillin, and streptomycin in an atmosphere of 5% CO2 and 95% air at 37°C. The ZM39923 inhibitor treatment at the dose determined using the Cell Counting Kit-8[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

ZM39923ZM 39923ZM-39923JAKJanus kinaseInhibitorinhibitorinhibit

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Product Name:
ZM39923 hydrochloride
Cat. No.:
HY-12589
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