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Cat. No.: HY-187103

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JAK1-IN-22

JAK1-IN-22 is a JAK1-selective inhibitor with an IC₅₀ of 1.84 μM. JAK1-IN-22 exerts no significant inhibitory effect on JAK2 and JAK3. JAK1-IN-22 can be used in the research of JAK1-related diseases such as asthma, alopecia areata, and type 1 diabetes.

For research use only. We do not sell to patients.

CAS No.: 2241039-80-3
Formula: C₂₈H₃₁F₂N₇O₄S
Molecular Weight:599.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

JAK1-IN-22 Chemical Structure

CAS No.: 2241039-80-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

JAK1

1.84 μM (IC₅₀)

All JAK Isoforms :

In Vitro

JAK1-IN-22 (Example 34) inhibits IL-13-induced STAT6 reporter gene activity in U937-STAT6-Luc cells with an IC₅₀ > 4.20 μM; it exhibits an IC₅₀ of 1.84 μM in recombinant JAK1 enzymatic assays, while the IC₅₀ values against JAK2 and JAK3 are both > 30 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2241039-80-3
Molecular Weight 599.66
Formula C₂₈H₃₁F₂N₇O₄S
SMILES

N(C([C@H](COC)N1CCN(C)CC1)=O)C2=C3C(C(=CN3)C4=NC(NC5=C(F)C(S(C)(=O)=O)=CC=C5)=NC=C4F)=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nilsson KM, et al. JAK1 selective inhibitors. International Patent Application No. WO 2018/134213 A1. Published July 26, 2018.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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JAK1-IN-22

All JAK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

JAK1-IN-22 Related Classifications

HY-187103 Related Classifications