JAK1-IN-22
JAK1-IN-22 is a JAK1-selective inhibitor with an IC50 of 1.84 μM. JAK1-IN-22 exerts no significant inhibitory effect on JAK2 and JAK3. JAK1-IN-22 can be used in the research of JAK1-related diseases such as asthma, alopecia areata, and type 1 diabetes.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2241039-80-3
- 分子式: C28H31F2N7O4S
- 分子量:599.66
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
JAK1 1.84 μM (IC50) |
体外実験
JAK1-IN-22 (Example 34) inhibits IL-13-induced STAT6 reporter gene activity in U937-STAT6-Luc cells with an IC50 > 4.20 μM; it exhibits an IC50 of 1.84 μM in recombinant JAK1 enzymatic assays, while the IC50 values against JAK2 and JAK3 are both > 30 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2241039-80-3
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分子量 599.66
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分子式 C28H31F2N7O4S
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SMILES
N(C([C@H](COC)N1CCN(C)CC1)=O)C2=C3C(C(=CN3)C4=NC(NC5=C(F)C(S(C)(=O)=O)=CC=C5)=NC=C4F)=CC=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
JAK1-IN-22 関連分類
HY-187103 関連分類
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Keywords
- JAK1-IN-22
- 2241039-80-3
- JAK
- JAK1 inhibitor
- selective JAK1 inhibitor
- Janus kinase 1
- JAK2 sparing
- JAK3 sparing
- indolylpyrimidine
- pyrimidine derivative
- S-enantiomer
- U937 cells
- STAT6 reporter assay
- IL-13 signaling
- asthma
- alopecia areata
- type 1 diabetes
- rheumatoid arthritis
- psoriasis
- lupus
- multiple sclerosis
- atopic dermatitis
- ulcerative colitis
- Crohn's disease
- autoimmune disease
- inflammatory disease
- C3H/HeJ mice
- Brown Norway rats
- OVA lung inflammation model
- Inhibitor
- inhibitor
- inhibit