2241039-80-3
Chemical Structure
JAK1-IN-22
- CAS No.: 2241039-80-3
- Formula:C28H31F2N7O4S
- Molecular Weight:599.66
IUPAC Name: (S)-N-(3-(5-fluoro-2-((2-fluoro-3-(methylsulfonyl)phenyl)amino)pyrimidin-4-yl)-1H-indol-7-yl)-3-methoxy-2-(4-methylpiperazin-1-yl)propanamide
InChIKey: JNUZADQZHYFJGW-QFIPXVFZSA-N
SMILES: N(C([C@H](COC)N1CCN(C)CC1)=O)C2=C3C(C(=CN3)C4=NC(NC5=C(F)C(S(C)(=O)=O)=CC=C5)=NC=C4F)=CC=C2
Biological Activity: JAK1-IN-22 is a JAK1-selective inhibitor with an IC50 of 1.84 μM. JAK1-IN-22 exerts no significant inhibitory effect on JAK2 and JAK3. JAK1-IN-22 can be used in the research of JAK1-related diseases such as asthma, alopecia areata, and type 1 diabetes[1].
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JAK1-IN-22 | JAK1-IN-22 is a JAK1-selective inhibitor with an IC50 of 1.84 μM. JAK1-IN-22 exerts no significant inhibitory effect on JAK2 and JAK3. JAK1-IN-22 can be used in the research of JAK1-related diseases such as asthma, alopecia areata, and type 1 diabetes. | |||||||||||||||||||||
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Keywords
