(R)-Blovacitinib
(R)-Blovacitinib ((R)-TUL01101) is a JAK1-selective inhibitor with an IC50 of 45 nM. (R)-Blovacitinib inhibits JAK1-mediated cytokine signaling pathways. (R)-Blovacitinib can be used for the research of rheumatoid arthritis.
For research use only. We do not sell to patients.
- CAS No.: 2411222-96-1
- Formula: C22H25F2N5O2
- Molecular Weight:429.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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JAK1 45 nM (IC50) |
(R)-Blovacitinib (compound 35) inhibits purified human JAK1 with an IC50 of 45 nM, showing 11.7-fold selectivity over JAK2 and 8.0-fold selectivity over TYK2, with no significant inhibition of JAK3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2411222-96-1
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Molecular Weight 429.46
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Formula C22H25F2N5O2
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SMILES
O=C([C@@H]1C(F)(C1)F)N2CC3(CCC(C4=CC=CC5=NC(NC(C6CC6)=O)=NN45)CC3)C2
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Synonyms
(R)-TUL01101
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(R)-Blovacitinib Related Classifications
HY-152080A Related Classifications
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