Flonoltinib monomaleate
Based on 1 publication(s) in Google Scholar
Flonoltinib maleate is a potent and orally active dual JAK2/FLT3 inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. JAK2/FLT3-IN-1 has anti-cancer activity.
For research use only. We do not sell to patients.
- CAS No.: 3062214-21-2
- Formula: C29H38FN7O5
- Molecular Weight:583.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Flonoltinib monomaleate
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Biological Activity
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JAK1 26 nM (IC50) |
JAK2 0.7 nM (IC50) |
JAK3 39 nM (IC50) |
Flonoltinib maleate (0.008-1 μM; for 2 hours) down-regulates p-FLT3 in a dose-dependent manner[1].
Flonoltinib maleate (5-100 nM; for 2 hours) has a dose-dependent effect on the induction of apoptosis in the MV4-11 cells[1].
Flonoltinib maleate (5-100 nM; for 2 hours) strongly induces cell cycle arrest with a G1/G0 percentage of 85% at 100 nM in the MV4-11 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MV4-11 and SET-2 cells
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Concentration:0.008, 0.04, 0.2, 1 μM
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Incubation Time:For 2 hours
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Result:Down-regulated p-FLT3 in a dose-dependent manner from 0.008 to 1 μM.
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Cell Line:MV4-11 and SET-2 cells
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Concentration:5, 10, 50, 100 nM
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Incubation Time:For 2 hours
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Result:Had a dose-dependent effect on the induction of apoptosis in the MV4-11 cells.
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Cell Line:MV4-11 cells
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Concentration:5, 10, 50, 100 nM
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Incubation Time:For 2 hours
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Result:Induced cell cycle arrest with a G1/G0 percentage of 85% at 100 nM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NOD/SCID mouse models[1]
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Dosage:30 and 60 mg/kg
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Administration:Oral administration; daily; for 14 days
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Result:Exhibited significant antitumor effects.
The tumor growth inhibitory rates (TGI) were respective 58% and 93% in the MV4-11-bearing mice model.
Chemical Information
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CAS No. 3062214-21-2
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Molecular Weight 583.65
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Formula C29H38FN7O5
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SMILES
OCCN(C1CCN(C2=CC=C(NC3=NC=C(C)C(C4=CN(C(C)C)N=C4)=N3)C=C2F)CC1)C.O=C(O)/C=C\C(O)=O
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Synonyms
JAK2/FLT3-IN-1 monomaleate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Immunol
Tumor Environment Promotes Lnc57Rik-Mediated Suppressive Function of Myeloid-Derived Suppressor Cells. [Abstract]2022 Oct 1;209(7):1401-1413. PMID: 36038289
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Flonoltinib monomaleate Related Classifications
HY-130247B Related Classifications
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