3062214-21-2
3062214-21-2
Chemical Structure
Flonoltinib monomaleate
Synonym(s): JAK2/FLT3-IN-1 monomaleate
- CAS No.: 3062214-21-2
- Formula:C29H38FN7O5
- Molecular Weight:583.65
InChIKey: NLVFJAJYGCZTRV-BTJKTKAUSA-N
SMILES: OCCN(C1CCN(C2=CC=C(NC3=NC=C(C)C(C4=CN(C(C)C)N=C4)=N3)C=C2F)CC1)C.O=C(O)/C=C\C(O)=O
Biological Activity: Flonoltinib maleate is a potent and orally active dual JAK2/FLT3 inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. JAK2/FLT3-IN-1 has anti-cancer activity[1].
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Flonoltinib monomaleate | Flonoltinib maleate is a potent and orally active dual JAK2/FLT3 inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. JAK2/FLT3-IN-1 has anti-cancer activity. | |||||||||||||||||||||
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References
Keywords
