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Cat. No.: HY-130247C

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Flonoltinib sulfate

(Synonyms: JAK2/FLT3-IN-1 sulfate)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Flonoltinib maleate is a potent and orally active dual JAK2/FLT3 inhibitor with IC₅₀ values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. Flonoltinib maleate has anti-cancer activity.

For research use only. We do not sell to patients.

CAS No.: 2568842-57-7
Formula: C₂₅H₃₆FN₇O₅S
Molecular Weight:565.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Flonoltinib sulfate Chemical Structure

CAS No.: 2568842-57-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

All JAK Isoforms :

In Vitro

Flonoltinib maleate (0.008-1 μM; for 2 hours) down-regulates p-FLT3 in a dose-dependent manner^[1].
Flonoltinib maleate (5-100 nM; for 2 hours) has a dose-dependent effect on the induction of apoptosis in the MV4-11 cells^[1].
Flonoltinib maleate (5-100 nM; for 2 hours) strongly induces cell cycle arrest with a G1/G0 percentage of 85% at 100 nM in the MV4-11 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Flonoltinib maleate (30 and 60 mg/kg/day; p.o.; for 14 days) exhibits significant antitumor effects^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2568842-57-7
Molecular Weight 565.66
Formula C₂₅H₃₆FN₇O₅S
SMILES

O=S(O)(O)=O.FC1=CC(NC2=NC(C3=CN(C(C)C)N=C3)=C(C)C=N2)=CC=C1N4CCC(CC4)N(CCO)C
Synonyms

JAK2/FLT3-IN-1 sulfate
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

J Immunol

Tumor Environment Promotes Lnc57Rik-Mediated Suppressive Function of Myeloid-Derived Suppressor Cells. [Abstract]

2022 Oct 1;209(7):1401-1413. PMID: 36038289

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang T, et al. Discovery of Potent and Orally Effective Dual JAK2/FLT3 Inhibitors for the Treatment of AcuteMyelogenous Leukemia and Myeloproliferative Neoplasms. J Med Chem. 2019 Oct 31. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Flonoltinib sulfate

1 Cited Publications

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Purity & Documentation
References

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Flonoltinib sulfate

Publications Citing Use of MedChemExpress (MCE) Flonoltinib sulfate

All JAK Isoforms

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

Calculators

Help & FAQs

Flonoltinib sulfate Related Classifications

HY-130247C Related Classifications