JAK1/STAT3-IN-1
JAK1/STAT3-IN-1 (compound 4f) is an anti-AD (atopic dermatitis) agent by inhibiting JAK1/STAT3 signaling pathway. JAK1/STAT3-IN-1 inhibits NO generation with an IC50 of 2.17 μM. JAK1/STAT3-IN-1 improves the skin condition of AD-like mice, reduces inflammatory infiltration, inhibits the expressions of p-JAK1/JAK1 and p-STAT3/STAT3, and mitigates the excessive immune response on Calcipotriol (HY-10001) (MC903)-induced AD-like mice.
For research use only. We do not sell to patients.
- Formula: C30H33FN4O3S
- Molecular Weight:548.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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JAK1 |
STAT3 |
NO production 2.17 μM (IC50) |
Chemical Information
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Molecular Weight 548.67
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Formula C30H33FN4O3S
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SMILES
O=C(/C=C/C1=CC=C(N2CCN(C)CC2)C=C1)C3=CC=C(N4CCN(S(C5=CC=C(F)C=C5)(=O)=O)CC4)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JAK1/STAT3-IN-1 Related Classifications
HY-170977 Related Classifications
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