2. Apoptosis Others NF-κB Stem Cell/Wnt
  3. Apoptosis Drug Derivative NF-κB Wnt
  4. Antiproliferative agent-76

Antiproliferative agent-76 (Compound II-2) is an 8-sulfonamidoquinoline derivative and a selective anticancer agent. Antiproliferative agent-76 blocks the NF-κB and WNT signaling pathways. Antiproliferative agent-76 promotes cancer cell Apoptosis. Antiproliferative agent-76 exhibits anticancer activity against colorectal cancer and leukemia.

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Antiproliferative agent-76

Antiproliferative agent-76 Chemical Structure

CAS No. : 33757-62-9

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Antiproliferative agent-76 Related Antibodies

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Description

Antiproliferative agent-76 (Compound II-2) is an 8-sulfonamidoquinoline derivative and a selective anticancer agent. Antiproliferative agent-76 blocks the NF-κB and WNT signaling pathways. Antiproliferative agent-76 promotes cancer cell Apoptosis. Antiproliferative agent-76 exhibits anticancer activity against colorectal cancer and leukemia[1].

In Vitro

Antiproliferative agent-76 (10 μM; 48 h) potently inhibits the proliferation of HCT116 colorectal cancer cells, with an IC50 of 1.0 ± 0.13 μM[1].
Antiproliferative agent-76 (10 μM; 48 h) inhibits the proliferation of HT-29 colorectal cancer cells, with an IC50 of 5.3 ± 0.84 μM[1].
Antiproliferative agent-76 (10 μM; 48 h) inhibits the proliferation of Mv4;11 myeloid leukemia cells, with an IC50 of 7.6 ± 0.65 μM[1].
Antiproliferative agent-76 (10 μM) selectively inhibits the proliferation of 8 cancer cell lines (inhibition rate >80% at 10 μM), while shows low activity against normal 786-O and L-02 cells[1].
Antiproliferative agent-76 (1.25-5 μM; 48 h) induces apoptosis in HCT116 colorectal cancer cells in a concentration-dependent manner, with the apoptosis rate reaching 80% after treatment with 5 μM for 48 h[1].
Antiproliferative agent-76 (II-2) (1.25-2.5 μM; 48 h) induces G2/M cell cycle arrest in HCT116 colorectal cancer cells in a concentration-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antiproliferative agent-76 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: Mv4;11 myeloid leukemia cells
Concentration: 10 μM
Incubation Time: 48 h
Result: Achieved 53 ± 8.0% proliferation inhibition at 10 μM.
Reached an IC50 value of 7.6 ± 0.65 μM.

Cell Cycle Analysis[1]

Cell Line: HCT116 colorectal cancer cells
Concentration: 1.25-2.5 μM
Incubation Time: 48 h
Result: Caused significant accumulation of cells in the G2 phase in a concentration-dependent manner.
Decreased the percentage of cells in the G1 phase in a concentration-dependent manner.
Molecular Weight

329.33

Formula

C15H11N3O4S
CAS No.
SMILES

O=[N+](C1=CC=C(C=C1)S(=O)(NC2=C3N=CC=CC3=CC=C2)=O)[O-]
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References
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Antiproliferative agent-76 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiproliferative agent-7633757-62-9Antiproliferative agent76Antiproliferative agent 76ApoptosisDrug DerivativeNF-κBWntDrug derivativeNuclear factor-κBNuclear factor-kappaBNF-κB signaling pathwaysHT-29 colorectal cancer cellsIκBαWNT/β-catenin signaling pathwaysHCT116 colorectal cancer cellsL-02 cellscolorectal cancerMv4;11 myeloid leukemia cellsSKA cellsP65Inhibitorinhibitorinhibit

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