Antiproliferative agent-76
Antiproliferative agent-76 (Compound II-2) is an 8-sulfonamidoquinoline derivative and a selective anticancer agent. Antiproliferative agent-76 blocks the NF-κB and WNT signaling pathways. Antiproliferative agent-76 promotes cancer cell Apoptosis. Antiproliferative agent-76 exhibits anticancer activity against colorectal cancer and leukemia.
For research use only. We do not sell to patients.
- CAS No.: 33757-62-9
- Formula: C15H11N3O4S
- Molecular Weight:329.33
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HUVEC | IC50 |
1.5 μM
Compound: 6
|
Inhibition of TNF-alpha-stimulated human NF-kappaB p65 RelA subunit nuclear translocation in HUVEC
Inhibition of TNF-alpha-stimulated human NF-kappaB p65 RelA subunit nuclear translocation in HUVEC
|
[PMID: 18024113] |
Antiproliferative agent-76 (10 μM; 48 h) potently inhibits the proliferation of HCT116 colorectal cancer cells, with an IC50 of 1.0 ± 0.13 μM[1].
Antiproliferative agent-76 (10 μM; 48 h) inhibits the proliferation of HT-29 colorectal cancer cells, with an IC50 of 5.3 ± 0.84 μM[1].
Antiproliferative agent-76 (10 μM; 48 h) inhibits the proliferation of Mv4;11 myeloid leukemia cells, with an IC50 of 7.6 ± 0.65 μM[1].
Antiproliferative agent-76 (10 μM) selectively inhibits the proliferation of 8 cancer cell lines (inhibition rate >80% at 10 μM), while shows low activity against normal 786-O and L-02 cells[1].
Antiproliferative agent-76 (1.25-5 μM; 48 h) induces apoptosis in HCT116 colorectal cancer cells in a concentration-dependent manner, with the apoptosis rate reaching 80% after treatment with 5 μM for 48 h[1].
Antiproliferative agent-76 (II-2) (1.25-2.5 μM; 48 h) induces G2/M cell cycle arrest in HCT116 colorectal cancer cells in a concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Mv4;11 myeloid leukemia cells
-
Concentration:10 μM
-
Incubation Time:48 h
-
Result:Achieved 53 ± 8.0% proliferation inhibition at 10 μM.
Reached an IC50 value of 7.6 ± 0.65 μM.
-
Cell Line:HCT116 colorectal cancer cells
-
Concentration:1.25-2.5 μM
-
Incubation Time:48 h
-
Result:Caused significant accumulation of cells in the G2 phase in a concentration-dependent manner.
Decreased the percentage of cells in the G1 phase in a concentration-dependent manner.
Chemical Information
-
CAS No. 33757-62-9
-
Appearance Solid
-
Molecular Weight 329.33
-
Formula C15H11N3O4S
-
SMILES
O=[N+](C1=CC=C(C=C1)S(=O)(NC2=C3N=CC=CC3=CC=C2)=O)[O-]
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antiproliferative agent-76 Related Classifications
HY-182053 Related Classifications
Powered by Bioz
- Antiproliferative agent-76
- 33757-62-9
- Antiproliferative agent76
- Antiproliferative agent 76
- Apoptosis
- Drug Derivative
- NF-κB
- Wnt
- NF-κB signaling pathways
- HT-29 colorectal cancer cells
- IκBα
- WNT/β-catenin signaling pathways
- HCT116 colorectal cancer cells
- L-02 cells
- colorectal cancer
- Mv4;11 myeloid leukemia cells
- SKA cells
- P65
- Inhibitor
- inhibitor
- inhibit