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Aristolochic acid A

(Synonyms: Aristolochic acid I; TR 1736)
10 Cited Publications
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Based on 10 publication(s) in Google Scholar

Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines.

For research use only. We do not sell to patients.

  • Purity: 99.91%
  • CAS No.: 313-67-7
  • Formula: C17H11NO7
  • Molecular Weight:341.27
  • Storage:

    4°C, protect from light

    * In solvent : -80°C, 1 year; -20°C, 6 months (protect from light)

  • Aristolochic acid A Chemical Structure
    Aristolochic acid A Chemical Structure
  • Experimental Validation Results for Aristolochic acid A
  • Experimental Validation Results for Aristolochic acid A
  • Experimental Validation Results for Aristolochic acid A
  • Experimental Validation Results for Aristolochic acid A
  • Experimental Validation Results for Aristolochic acid A
  • Experimental Validation Results for Aristolochic acid A
  • Experimental Validation Results for Aristolochic acid A
CAS No.: 313-67-7
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Bio/Physico-chemical AssayIn Vivo Efficacy StudyHistological Imaging/StainingIFCell Proliferation/Viability AssayWB
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  • Aristolochic acid A Chemical Structure
    Aristolochic acid A Chemical Structure
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    Aristolochic acid A purchased from MedChemExpress. Usage Cited in: Nature. 2024 Jul;631(8020):459-466. [Abstract]

    Customer Validation
     FLIPR Ca2+ assay responses in wild-type (WT) TAS2R14 and mutants in pockets 1, 2 and 3, following Aristolochic acid A (150 μM) stimulation. The negative logarithmic half-maximal effective concentration (pEC50) and the maximum response (Emax) values were calculated from the concentration–response curves.

  • 1/16

    Aristolochic acid A purchased from MedChemExpress. Usage Cited in: Precis Clin Med. 2022 Sep 22;5(4):pbac023. [Abstract]

    Customer Validation
     Aristolochic acid A (AAI, 2 mg/kg/day). Body weight of mice in Control, AAI-4w, and AAI-8w groups.

  • 1/16

    Aristolochic acid A purchased from MedChemExpress. Usage Cited in: Precis Clin Med. 2022 Sep 22;5(4):pbac023. [Abstract]

    Customer Validation
     Aristolochic acid A (AAI, 2 mg/kg/day, 4 or 8 weeks). H&E staining showed pathological changes of mice livers after AAI treatment, scale bar = 100 μm.

  • 1/16

    Aristolochic acid A purchased from MedChemExpress. Usage Cited in: Precis Clin Med. 2022 Sep 22;5(4):pbac023. [Abstract]

    Customer Validation
     Aristolochic acid A (AAI, 2 mg/kg/day, 4 or 8 weeks). Liver/body weight ratio after AAI treatment (n = 5, ***P < 0.001, ns = not significant). Effects of AAI on the levels of serum ALT and AST in the indicated groups (n = 5, *P < 0.05, **P < 0.01, ns = not significant).

  • 1/16

    Aristolochic acid A purchased from MedChemExpress. Usage Cited in: Precis Clin Med. 2022 Sep 22;5(4):pbac023. [Abstract]

    Customer Validation
     Aristolochic acid A (AAI, 2 mg/kg/day, 4 or 8 weeks). IF staining of p-STAT3 (red) in the three groups, and the nuclei were stained by Hoechst (blue), scale bar = 50 µm.

  • 1/16

    Aristolochic acid A purchased from MedChemExpress. Usage Cited in: Precis Clin Med. 2022 Sep 22;5(4):pbac023. [Abstract]

    Customer Validation
     Aristolochic acid A (AAI, 2 mg/kg/day, 4 or 8 weeks). IF staining of Bcl-2 (green) and Bax (Red) to detect endothelial cell apoptosis in the three groups, the nucleus was labelled by Hoechst (blue), scale bar = 40 µm.

  • 1/16

    Aristolochic acid A purchased from MedChemExpress. Usage Cited in: Precis Clin Med. 2022 Sep 22;5(4):pbac023. [Abstract]

    Customer Validation
     Aristolochic acid A (AAI, 2 mg/kg/day, 4 or 8 weeks). Western blot was used to detect the expression of apoptotic signaling pathway-related markers cleaved-caspase 3, Bax, and Bcl-2 in liver tissues after AAI treatment.

  • Aristolochic acid A