2. PROTAC Immunology/Inflammation
  3. BCL6 PROTACs
  4. ARV-393

ARV-393 is a potent and orally active BCL6 PROTAC degrader. ARV-393 induces ubiquitination of BCL6 and its subsequent degradation by the proteasome. ARV-393 has the potential for the research of advanced non-hodgkin lymphoma.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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ARV-393

ARV-393 構造式

CAS 番号 : 2851885-95-3

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 1344 在庫あり
Solution
10 mM * 1 mL in DMSO USD 1344 在庫あり
Solid
1 mg $272 在庫あり
5 mg $680 在庫あり
10 mg $1100 在庫あり
25 mg $2200 在庫あり
50 mg $3500 在庫あり
100 mg $5500 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

ARV-393 関連抗体

Top Publications Citing Use of Products

PROTACs アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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製品説明

ARV-393 is a potent and orally active BCL6 PROTAC degrader. ARV-393 induces ubiquitination of BCL6 and its subsequent degradation by the proteasome. ARV-393 has the potential for the research of advanced non-hodgkin lymphoma[1][2][3].

IC50 & Target

BCL6[1]
体外実験

ARV-393 has DC50 and GI50 values of <1 nM in multiple cell lines of diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ARV-393 関連抗体
体内実験

ARV-393 (3, 10, 30 mg/kg; po; once daily for 23 days) shows anticancer activity in xenograft model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (OCI-Ly1 cell line xenograft model)[3]
Dosage: 3, 10, 30 mg/kg
Administration: PO; once daily for 23 days (3 mg/kg; twice daily for 23 days)
Result: Ihibited tumor growth and induced BCL6 protein degradation.
臨床実験
分子量

898.42

分子式

C46H53ClFN9O7
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

ClC1=CN=C(N2CCC(O[C@@H]3C[C@@H](N4CCC(C5=C(F)C(CN(C6CCC(NC6=O)=O)C7=O)=C7C=C5)CC4)C3)CC2)N=C1NC8=CC(C=C(OCC(NC)=O)C(N9C(C)C)=O)=C9C=C8
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

DMSO : 20 mg/mL (22.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1131 mL 5.5653 mL 11.1307 mL
5 mM 0.2226 mL 1.1131 mL 2.2261 mL
10 mM 0.1113 mL 0.5565 mL 1.1131 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

V1

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
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純度とドキュメンテーション

純度: 99.75%

COA (253 KB) HNMR (362 KB) RP-HPLC (256 KB) LCMS (338 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1131 mL 5.5653 mL 11.1307 mL 27.8266 mL
5 mM 0.2226 mL 1.1131 mL 2.2261 mL 5.5653 mL
10 mM 0.1113 mL 0.5565 mL 1.1131 mL 2.7827 mL
15 mM 0.0742 mL 0.3710 mL 0.7420 mL 1.8551 mL
20 mM 0.0557 mL 0.2783 mL 0.5565 mL 1.3913 mL
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ARV-393 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ARV-3932851885-95-3ARV393ARV 393BCL6PROTACsB-cell lymphoma 6 proteinB-cell lymphoma 5 protein (BCL-5)Zinc finger and BTB domain-containing protein 27Zinc finger protein 51Orally activeubiquitin-proteasome systemE3 ligasediffuse large B-cell lymphomaDLBCLBurkitt lymphomanon-Hodgkin lymphomaInhibitorinhibitorinhibit

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製品名:
ARV-393
製品番号:
HY-158105
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