2. Anticorps inhibiteurs
  3. Biosimilar Antibodies
  4. Monoclonal Antibodies
  5. Bavituximab

Bavituximab  (Synonyms: Anti-Human Phosphatidylserine Recombinant Antibody; PGN-401; CH3G4)

Cat. No.: HY-P99279 Pureté: 97.00%
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Bavituximab (Anti-Human Phosphatidylserine Recombinant Antibody) is a phosphatidylserine (PS)-targeting monoclonal antibody, suppresses tumor growth by targeting tumor vasculature and reactivating antitumor immunity. Bavituximab plus Paclitaxel (HY-B0015) and Carboplatin (HY-17393), have enhanced inhibition on non-small-cell lung cancer.

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CAS No. : 648904-28-3

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Based on 1 publication(s) in Google Scholar

Other Forms of Bavituximab:

Bavituximab Related Antibodies

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1 Publications Citing Use of MCE Bavituximab

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Description

Bavituximab (Anti-Human Phosphatidylserine Recombinant Antibody) is a phosphatidylserine (PS)-targeting monoclonal antibody, suppresses tumor growth by targeting tumor vasculature and reactivating antitumor immunity. Bavituximab plus Paclitaxel (HY-B0015) and Carboplatin (HY-17393), have enhanced inhibition on non-small-cell lung cancer[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

Phosphatidylserine
In Vitro

Bavituximab binds to exposed phosphatidylserine (PS) molecules via the serum protein, β2-glycoprotein 1 (β2GP1)[1].
Bavituximab binds PS to induces antibody-dependent cellular cytotoxicity, resulting in tumor vessel destruction[1].
Bavituximab (10 μg/mL; 48 h) binds to exposed phosphatidylserine (PS) via 10 μM Sorafenib inducing exposure in HUVEC and bEnd.3 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bavituximab Related Antibodies
In Vivo

Sorafenib induces exposure of anionic phospholipids in tumor model in mice. Bavituximab (100 μg/mouse; i.v.; single dose; 48 h after Sorafenib treatment) traces phosphatidylserine exposure in vivo[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice bearing subcutaneous PLC/PRF/5, C3A, and Huh7 tumors[2]
Dosage: 100 μg/mouse (Bavituximab/β2GP1)
Administration: Intravenous injection single dose; 48 h after sorafenib treatment (100 mg/kg; p.o.; single dose)
Result: Traced phosphatidylserine exposure in vivo in mice with tumors.
Essai clinique
Gene ID

23761  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Masse moléculaire

145.336 kDa

CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Bavituximab]
Livraison

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Pureté et documentation
Références
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Bavituximab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bavituximab648904-28-3Anti-Human Phosphatidylserine Recombinant Antibody PGN-401 CH3G4PGN401PGN 401PGN-401Otherstumor-specific vascularimmune-modulatingInhibitorinhibitorinhibit

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HY-P99279
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