cGAMP (Synonyms: Cyclic GMP-AMP; 3',3'-cGAMP)

Name: cGAMP
Brand: MedChemExpress
SKU: HY-12512
Rating: 5.0 (26 reviews)

製品番号: HY-12512 純度: 98.47%: Data Sheet SDS COA 取扱説明書
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cGAMP (Cyclic GMP-AMP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators.

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CAS 番号 : 849214-04-6

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 1410	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 1410	在庫あり	Estimated Time of Arrival: December 31
Solid
500 μg	$190	在庫あり	Estimated Time of Arrival: December 31
1 mg	$330	在庫あり	Estimated Time of Arrival: December 31
5 mg	$950	在庫あり	Estimated Time of Arrival: December 31
10 mg	$1520	在庫あり	Estimated Time of Arrival: December 31
25 mg	$3040	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

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This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 26 publication(s) in Google Scholar

Other Forms of cGAMP:

cGAMP disodium 在庫あり
cGAMP diammonium 在庫あり

顧客検証

Cell Imaging/Staining

RT-PCR

Bio/Physico-chemical Assay

: cGAMP purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Oct 1;10(1):321. [Abstract]; cGAMP accelerated calcium deposition in VSMCs.

: cGAMP purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Oct 1;10(1):321. [Abstract]; cGAMP increased the calcium content in VSMCs.

: cGAMP purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Dec 4;15(1):10543. [Abstract]; cGAMP (2.5 or 10 μM, 24 h) increased OLFM4 protein expression in HGC-27 cells.

: cGAMP purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Dec 4;15(1):10543. [Abstract]; cGAMP (10 μM, 6, 12, and 24 h) increased OLFM4 mRNA expression in HGC-27 cells.

: cGAMP purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2025 Jun;32(6):1167-1179. [Abstract]; cGAMP (0, 2, and 200 nM; 3 or 6 h) increased STING phosphorylation at 3 h with 200 nM, but not at 6 h in THP-1 cells.

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生物活性
純度とドキュメンテーション
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製品説明

IC₅₀ & Target

Endogenous Metabolite

Cellular Effect

Cell Line	Type	Value	Description	References
H69AR	EC₅₀	4.74 μM Compound: 3',3'-cGAMP	Activation of wild-type human STING expressed in human THP1-Dual cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter activation measured after 7 hrs by luciferase reporter gene assay Activation of wild-type human STING expressed in human THP1-Dual cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter activation measured after 7 hrs by luciferase reporter gene assay	[PMID: 34019405]
H69AR	EC₅₀	58.46 μM Compound: 3',3'-cGAMP	Activation of wild-type human STING expressed in digitonin treated human THP1-Dual cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter activation measured after 30 mins by luciferase reporter gene assay Activation of wild-type human STING expressed in digitonin treated human THP1-Dual cells co-expressing IRF3-activated ISRE assessed as IRF3 reporter activation measured after 30 mins by luciferase reporter gene assay	[PMID: 34019405]
L929	EC₅₀	20 nM Compound: 3',3'-cGAMP	Inhibition of STING in mouse L929 cells assessed as reduction in cGAMP induce IFNbeta expression measured after 4 hrs by qRT-PCR Inhibition of STING in mouse L929 cells assessed as reduction in cGAMP induce IFNbeta expression measured after 4 hrs by qRT-PCR	[PMID: 32206239]
PBMC	EC₅₀	15.14 μM Compound: 3',3'-cGAMP	Induction of INF-gamma production in healthy human PBMC incubated for 16 hrs Induction of INF-gamma production in healthy human PBMC incubated for 16 hrs	[PMID: 34019405]
PBMC	EC₅₀	17.25 μM Compound: 3'3'-cGAMP	Induction of IFNgamma secretion in human PBMC incubated for 16 hrs Induction of IFNgamma secretion in human PBMC incubated for 16 hrs	[PMID: 36201304]
PBMC	EC₅₀	18.72 μM Compound: 3'3'-cGAMP	Induction of TNFalpha secretion in human PBMC incubated for 16 hrs Induction of TNFalpha secretion in human PBMC incubated for 16 hrs	[PMID: 36201304]
PBMC	EC₅₀	26.71 μM Compound: 3',3'-cGAMP	Induction of INF-alpha production in healthy human PBMC incubated for 16 hrs Induction of INF-alpha production in healthy human PBMC incubated for 16 hrs	[PMID: 34019405]
PBMC	EC₅₀	7.65 μM Compound: 3'3'-cGAMP	Induction of IFNalpha secretion in human PBMC incubated for 16 hrs Induction of IFNalpha secretion in human PBMC incubated for 16 hrs	[PMID: 36201304]
PBMC	EC₅₀	> 300 μM Compound: 3',3'-cGAMP	Induction of TNF-alpha production in healthy human PBMC incubated for 16 hrs Induction of TNF-alpha production in healthy human PBMC incubated for 16 hrs	[PMID: 34019405]

体外実験

cGAMP promotes the antigen-specific proliferation capacity of spleen cells in mice^[2].
cGAMP directly activates murine and human dendritic cells in vitro^[2].
On stimulation with cGAMP, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF)^[3].
cGAMP activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

cGAMP (5 μg; nostril mucosal adjuvant) promotes the antigen-specific cytokine production by spleen cells of immunized mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female C57BL/6 (H-2b) mice 6–8 weeks old^[2]
Dosage:	5 µg
Administration:	Nostril mucosal adjuvant
Result:	Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice.

分子量

674.41

分子式

C₂₀H₂₄N₁₀O₁₃P₂

CAS 番号

849214-04-6

Appearance

Solid

Color

White to yellow

SMILES

O=P(O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP4(O)=O)(O)OC[C@@H]5[C@@H](O4)[C@@H](O)[C@H](N6C=NC7=C6N=C(N)NC7=O)O5

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

H₂O : 180 mg/mL (266.90 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4828 mL	7.4139 mL	14.8278 mL
5 mM	0.2966 mL	1.4828 mL	2.9656 mL
10 mM	0.1483 mL	0.7414 mL	1.4828 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 99.22%

Select Batch:

データシート (278 KB) SDS (393 KB)

COA (252 KB) HNMR (258 KB) RP-HPLC (243 KB) MS (127 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Wu J, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15;339(6121):826-30. [Content Brief]

[2]. Skrnjug I, et al. Cyclic GMP-AMP displays mucosal adjuvant activity in mice. PLoS One. 2014 Oct 8;9(10):e110150. [Content Brief]

[3]. Liu Y, et al. Activated STING in a vascular and pulmonary syndrome. N Engl J Med. 2014 Aug 7;371(6):507-18. [Content Brief]

[4]. Ablasser A, et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 2013 Nov 28;503(7477):530-4. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.4828 mL	7.4139 mL	14.8278 mL	37.0694 mL
	5 mM	0.2966 mL	1.4828 mL	2.9656 mL	7.4139 mL
	10 mM	0.1483 mL	0.7414 mL	1.4828 mL	3.7069 mL
	15 mM	0.0989 mL	0.4943 mL	0.9885 mL	2.4713 mL
	20 mM	0.0741 mL	0.3707 mL	0.7414 mL	1.8535 mL
	25 mM	0.0593 mL	0.2966 mL	0.5931 mL	1.4828 mL
	30 mM	0.0494 mL	0.2471 mL	0.4943 mL	1.2356 mL
	40 mM	0.0371 mL	0.1853 mL	0.3707 mL	0.9267 mL
	50 mM	0.0297 mL	0.1483 mL	0.2966 mL	0.7414 mL
	60 mM	0.0247 mL	0.1236 mL	0.2471 mL	0.6178 mL
	80 mM	0.0185 mL	0.0927 mL	0.1853 mL	0.4634 mL
	100 mM	0.0148 mL	0.0741 mL	0.1483 mL	0.3707 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

cGAMP Related Classifications

Inflammation/Immunology

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cGAMP849214-04-6Cyclic GMP-AMP 3',3'-cGAMPSTINGStimulator of Interferon GenesTMEM173MITAERISMPYSsecond messengerantigencytosolic DNAinterferonsimmune mediatorsInhibitorinhibitorinhibit

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cGAMP (Synonyms: Cyclic GMP-AMP; 3',3'-cGAMP)

カスタマーレビュー

Other Forms of cGAMP:

cGAMP 関連抗体

顧客検証

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

cGAMP 関連抗体

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

cGAMP Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

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