2. Epigenetics Apoptosis
  3. Histone Acetyltransferase Apoptosis
  4. CHI-KAT8i5

CHI-KAT8i5 is a selective and orally active KAT8 inhibitor with a KD value of 19.72 μM. CHI-KAT8i5 does not bind to other proteins in HAT family (KAT2A, KAT2B, KAT5, and KAT7). CHI-KAT8i5 induces cancer cell apoptosis. CHI-KAT8i5 suppresses esophageal squamous cell carcinoma (ESCC) growth through targeting KAT8/c-Myc signaling pathway.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CHI-KAT8i5

CHI-KAT8i5 構造式

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 611 在庫あり
Solution
10 mM * 1 mL in DMSO USD 611 在庫あり
Solid
5 mg $530 在庫あり
10 mg $850 在庫あり
25 mg $1700 在庫あり
50 mg $2730 在庫あり
100 mg   お問い合わせ  
200 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

CHI-KAT8i5 関連抗体

Top Publications Citing Use of Products

Histone Acetyltransferase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
CBP/p300 GCN5/PCAF TIP60 MOZ/MORF HBO1

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

CHI-KAT8i5 is a selective and orally active KAT8 inhibitor with a KD value of 19.72 μM. CHI-KAT8i5 does not bind to other proteins in HAT family (KAT2A, KAT2B, KAT5, and KAT7). CHI-KAT8i5 induces cancer cell apoptosis. CHI-KAT8i5 suppresses esophageal squamous cell carcinoma (ESCC) growth through targeting KAT8/c-Myc signaling pathway[1].

IC50 & Target

KD value of 19.72 μM for KAT8
体外実験

CHI-KAT8i5 (0-72 h) inhibits cell proliferation of KYSE 30 and KYSE 150 cells with IC50s of 2-3 μΜ[1].
CHI-KAT8i5 (5-15 μM; 48 h) induces cancer cell apoptosis in a dose-dependent manner[1].
CHI-KAT8i5 (5-15 μM; 12 h) represses the NPM1 and PPAT transcript expression in a dose-dependent manner[1].
CHI-KAT8i5 (2-15 μM; 12 h) shows a dose-dependent decrease in H4K16ace and c-Myc upon[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CHI-KAT8i5 関連抗体

Apoptosis Analysis[1]

Cell Line: KYSE 30 and KYSE 150 cell lines
Concentration: 5 and 15 μM
Incubation Time: 48 h
Result: Could induce cancer cell apoptosis in a dose-dependent manner.

RT-PCR[1]

Cell Line: KYSE 30 and KYSE 150 cell lines
Concentration: 5 and 15 μM
Incubation Time: 12 h
Result: NPM1 and PPAT transcript expression were repressed.

Western Blot Analysis[1]

Cell Line: KYSE 30 and KYSE 150 cell lines
Concentration: 2 μΜ, 4 μΜ, 6 μΜ, 10 μΜ, 15 μΜ
Incubation Time: 12 h
Result: Observed a dose-dependent decrease in H4K16ace and c-Myc.
体内実験

CHI-KAT8i5 (50-200 mg/kg; oral gavage; once a day; 4-6-week) suppresses ESCC tumor growth in patient-derived ESCC xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-to eight-week-old severe combined immunodeficient (SCID) female mice were subdermally implanted with LEG379 tumor tissue[1].
Dosage: 50 or 200 mg/kg
Administration: Oral gavage; once a day; 4-6-week
Result: Significantly suppressed tumor growth in the LEG379 (KAT8 high expression levels) case in a dose-dependent manner.
The cell proliferation marker Ki-67 and c-Myc expression were decreased.
The H4K16ace levels were obviously suppressed
分子量

523.69

分子式

C23H29N3O5S3
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C2N=C(/C=C/C3=CC=C(S(=O)(N(CC)CC)=O)C(O)=C3)SC2=C1)(N(CC)CC)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (190.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9095 mL 9.5476 mL 19.0953 mL
5 mM 0.3819 mL 1.9095 mL 3.8191 mL
10 mM 0.1910 mL 0.9548 mL 1.9095 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9095 mL 9.5476 mL 19.0953 mL 47.7382 mL
5 mM 0.3819 mL 1.9095 mL 3.8191 mL 9.5476 mL
10 mM 0.1910 mL 0.9548 mL 1.9095 mL 4.7738 mL
15 mM 0.1273 mL 0.6365 mL 1.2730 mL 3.1825 mL
20 mM 0.0955 mL 0.4774 mL 0.9548 mL 2.3869 mL
25 mM 0.0764 mL 0.3819 mL 0.7638 mL 1.9095 mL
30 mM 0.0637 mL 0.3183 mL 0.6365 mL 1.5913 mL
40 mM 0.0477 mL 0.2387 mL 0.4774 mL 1.1935 mL
50 mM 0.0382 mL 0.1910 mL 0.3819 mL 0.9548 mL
60 mM 0.0318 mL 0.1591 mL 0.3183 mL 0.7956 mL
80 mM 0.0239 mL 0.1193 mL 0.2387 mL 0.5967 mL
100 mM 0.0191 mL 0.0955 mL 0.1910 mL 0.4774 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

CHI-KAT8i5 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHI-KAT8i5Histone AcetyltransferaseApoptosisHATsHATESCCColon cancerMelanomaGastric cancerNon-small cell adenocarcinomaLiver cancerPDXAnti-tumor.Inhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
CHI-KAT8i5
製品番号:
HY-168428
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.