2. Metabolic Enzyme/Protease
  3. Liposome
  4. CKK-E12

CKK-E12 is a ionizable lipid in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based research. CKK-E12 is highly selective toward liver parenchymal cell in vivo,

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CKK-E12

CKK-E12 화학구조

CAS No. : 1432494-65-9

사이즈 가격 재고 수량
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 4 publication(s) in Google Scholar

CKK-E12 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

CKK-E12 is a ionizable lipid in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based research. CKK-E12 is highly selective toward liver parenchymal cell in vivo,

In Vivo

CKK-E12 delivers siRNA in mice, rats and primates (ED50 is 0.002, 0.01 and 0.3 mg/kg, respectively)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
분자량

993.62

화학식

C60H120N4O6
CAS No.
Appearance

Liquid (Density: 0.963±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(C(CCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)N1)NC(CCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)C1=O
선적

Room temperature in continental US; may vary elsewhere.
보관
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 50 mg/mL (50.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0064 mL 5.0321 mL 10.0642 mL
5 mM 0.2013 mL 1.0064 mL 2.0128 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서

Purity: 98.0%

SDS (393 KB)

COA (244 KB) HNMR (311 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0064 mL 5.0321 mL 10.0642 mL 25.1605 mL
5 mM 0.2013 mL 1.0064 mL 2.0128 mL 5.0321 mL
10 mM 0.1006 mL 0.5032 mL 1.0064 mL 2.5161 mL
15 mM 0.0671 mL 0.3355 mL 0.6709 mL 1.6774 mL
20 mM 0.0503 mL 0.2516 mL 0.5032 mL 1.2580 mL
25 mM 0.0403 mL 0.2013 mL 0.4026 mL 1.0064 mL
30 mM 0.0335 mL 0.1677 mL 0.3355 mL 0.8387 mL
40 mM 0.0252 mL 0.1258 mL 0.2516 mL 0.6290 mL
50 mM 0.0201 mL 0.1006 mL 0.2013 mL 0.5032 mL
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CKK-E12 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CKK-E121432494-65-9LiposomeLipopeptide nanomaterialsLiver genetic disordersInhibitorinhibitorinhibit

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비고

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Inquiry Information

상품명:
CKK-E12
Cat. No.:
HY-134781
수량:
MCE Japan Authorized Agent:

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비고

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

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