CRBN ligand-13

Art. -Nr.: HY-W1004786 Reinheit: 97.94%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

CRBN ligand-13 is a CRBN-type E3 ubiquitin ligase ligand that can be used to prepare PROTAC.

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CRBN ligand-13 Chemische Struktur

CAS. Nr. : 3050687-70-9

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Auf Lager	Estimated Time of Arrival: December 31
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Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Ligands for E3 Ligase Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B KLHL41

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

CRBN ligand-13 is a CRBN-type E3 ubiquitin ligase ligand that can be used to prepare PROTAC.

IC₅₀ & Target

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

302.55

Formel

C₁₁H₉BrClNO₂

CAS. Nr.

3050687-70-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(C(C1=CC=CC(Br)=C1Cl)CC2)NC2=O

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 50 mg/mL (165.26 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3052 mL	16.5262 mL	33.0524 mL
5 mM	0.6610 mL	3.3052 mL	6.6105 mL
10 mM	0.3305 mL	1.6526 mL	3.3052 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 97.94%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (254 KB) HNMR (238 KB) LCMS (369 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Miletić N, et al. Workflow for E3 Ligase Ligand Validation for PROTAC Development. ACS Chem Biol. 2025 Feb 21;20(2):507-521. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3052 mL	16.5262 mL	33.0524 mL	82.6310 mL
	5 mM	0.6610 mL	3.3052 mL	6.6105 mL	16.5262 mL
	10 mM	0.3305 mL	1.6526 mL	3.3052 mL	8.2631 mL
	15 mM	0.2203 mL	1.1017 mL	2.2035 mL	5.5087 mL
	20 mM	0.1653 mL	0.8263 mL	1.6526 mL	4.1315 mL
	25 mM	0.1322 mL	0.6610 mL	1.3221 mL	3.3052 mL
	30 mM	0.1102 mL	0.5509 mL	1.1017 mL	2.7544 mL
	40 mM	0.0826 mL	0.4132 mL	0.8263 mL	2.0658 mL
	50 mM	0.0661 mL	0.3305 mL	0.6610 mL	1.6526 mL
	60 mM	0.0551 mL	0.2754 mL	0.5509 mL	1.3772 mL
	80 mM	0.0413 mL	0.2066 mL	0.4132 mL	1.0329 mL
	100 mM	0.0331 mL	0.1653 mL	0.3305 mL	0.8263 mL

CRBN ligand-13 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRBN ligand-133050687-70-9CRBN ligand13CRBN ligand 13Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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