Cytochalasin E

Name: Cytochalasin E
Brand: MedChemExpress
SKU: HY-N6772
Rating: 4.5 (0 reviews)

Cat. No.: HY-N6772 Purity: 99.90%: Data Sheet
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Handling Instructions
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Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Cytochalasin E is a potent actin depolymerization agent, and it binds and caps the barbed end of actin filaments to prevent actin elongation.

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Cytochalasin E 화학구조

CAS No. : 36011-19-5

사이즈	재고	수량
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	견적 받기
10 mg	견적 받기

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고객리뷰

Based on 1 Customer Validation

Other Forms of Cytochalasin E:

Cytochalasin E (Standard) 견적 받기

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.0062 3 Compound: 4	Cytotoxicity against human A549 cells after 72 hrs by MTT method Cytotoxicity against human A549 cells after 72 hrs by MTT method	[PMID: 16792402]
A549	IC₅₀	0.0062 3 Compound: 4	Cytotoxicity against human A549 cells after 72 hrs by MTT method Cytotoxicity against human A549 cells after 72 hrs by MTT method	[PMID: 16792402]
A549	IC₅₀	0.0062 3 Compound: 4	Cytotoxicity against human A549 cells after 72 hrs by MTT method Cytotoxicity against human A549 cells after 72 hrs by MTT method	[PMID: 16792402]
HUVEC	IC₅₀	0.0114 3 Compound: 7	Antiangiogenesis activity in HUVEC assessed as inhibition of VEGF-induced cell proliferation after 72 hrs by MTT assay Antiangiogenesis activity in HUVEC assessed as inhibition of VEGF-induced cell proliferation after 72 hrs by MTT assay	[PMID: 21718054]
HUVEC	IC₅₀	0.0114 3 Compound: 7	Antiangiogenesis activity in HUVEC assessed as inhibition of VEGF-induced cell proliferation after 72 hrs by MTT assay Antiangiogenesis activity in HUVEC assessed as inhibition of VEGF-induced cell proliferation after 72 hrs by MTT assay	[PMID: 21718054]
P388	IC₅₀	0.093 3 Compound: 4	Cytotoxicity against mouse P388 cells after 72 hrs by MTT method Cytotoxicity against mouse P388 cells after 72 hrs by MTT method	[PMID: 16792402]
P388	IC₅₀	0.093 3 Compound: 4	Cytotoxicity against mouse P388 cells after 72 hrs by MTT method Cytotoxicity against mouse P388 cells after 72 hrs by MTT method	[PMID: 16792402]
HUVEC	IC₅₀	0.0114 3 Compound: 7	Antiangiogenesis activity in HUVEC assessed as inhibition of VEGF-induced cell proliferation after 72 hrs by MTT assay Antiangiogenesis activity in HUVEC assessed as inhibition of VEGF-induced cell proliferation after 72 hrs by MTT assay	[PMID: 21718054]
P388	IC₅₀	0.093 3 Compound: 4	Cytotoxicity against mouse P388 cells after 72 hrs by MTT method Cytotoxicity against mouse P388 cells after 72 hrs by MTT method	[PMID: 16792402]

In Vitro

Cytochalasin E prominently inhibits the growth of A549 cells in a dose-dependent manner^[3].
Cytochalasin E could induce the up-regulation of autophagy-related protein (LC3-II) and SQSTM1/p62^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

495.56

화학식

C₂₈H₃₃NO₇

CAS No.

36011-19-5

Appearance

Solid

Color

White to off-white

SMILES

O=C1[C@]2(O3)[C@]([C@@H]([C@](O4)(C)[C@@H]4[C@]2([H])/C=C/C[C@@H](C([C@](C)(O)/C=C/OC3=O)=O)C)C)([H])[C@H](CC5=CC=CC=C5)N1

Structure Classification

Initial Source

Microorganisms

the fungus R. necatrix

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 50 mg/mL (100.90 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0179 mL	10.0896 mL	20.1792 mL
5 mM	0.4036 mL	2.0179 mL	4.0358 mL
10 mM	0.2018 mL	1.0090 mL	2.0179 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.90%

Select Batch:

Data Sheet (276 KB) SDS (477 KB)

COA (256 KB) RP-HPLC (916 KB)

Handling Instructions (2659 KB)

References

[1]. Udagawa T, et al. Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesisand tumor growth. J Pharmacol Exp Ther. 2000 Aug;294(2):421-7. [Content Brief]

[2]. Lu QY, et al. Green tea extract modulates actin remodeling via Rho activity in an in vitro multistep carcinogenicmodel. Clin Cancer Res. 2005 Feb 15;11(4):1675-83. [Content Brief]

[3]. Takanezawa Y, et al. Variation in the activity of distinct cytochalasins as autophagy inhibitiors in human lung A549 cells. Biochem Biophys Res Commun. 2017 Dec 16;494(3-4):641-647. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0179 mL	10.0896 mL	20.1792 mL	50.4480 mL
	5 mM	0.4036 mL	2.0179 mL	4.0358 mL	10.0896 mL
	10 mM	0.2018 mL	1.0090 mL	2.0179 mL	5.0448 mL
	15 mM	0.1345 mL	0.6726 mL	1.3453 mL	3.3632 mL
	20 mM	0.1009 mL	0.5045 mL	1.0090 mL	2.5224 mL
	25 mM	0.0807 mL	0.4036 mL	0.8072 mL	2.0179 mL
	30 mM	0.0673 mL	0.3363 mL	0.6726 mL	1.6816 mL
	40 mM	0.0504 mL	0.2522 mL	0.5045 mL	1.2612 mL
	50 mM	0.0404 mL	0.2018 mL	0.4036 mL	1.0090 mL
	60 mM	0.0336 mL	0.1682 mL	0.3363 mL	0.8408 mL
	80 mM	0.0252 mL	0.1261 mL	0.2522 mL	0.6306 mL
	100 mM	0.0202 mL	0.1009 mL	0.2018 mL	0.5045 mL

Cytochalasin E Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cytochalasin E36011-19-5AutophagyInhibitorinhibitorinhibit

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Cytochalasin E

고객리뷰

Other Forms of Cytochalasin E:

Cytochalasin E Related Antibodies

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

순도&문서

References

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Cytochalasin E Related Antibodies

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농도 희석 계산기

Complete Stock Solution Preparation Table

Cytochalasin E Related Classifications

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