2. Membrane Transporter/Ion Channel
  3. ASCT
  4. D-Isoleucine

D-イソロイシン  (Synonyms: D-Isoleucine; (R)-Isoleucine)

製品番号: HY-I1070 純度: 99.83%
COA 取扱説明書 Technical Support

D-Isoleucine is a selective competitive activator of the Asc-1 antiporter (Ki=0.98 mM). D-Isoleucine promotes the release of D-serine and glycine by binding to the Asc-1 protein on the neuronal cell membrane, and enhances NMDA receptor-dependent synaptic plasticity. D-Isoleucine can be used in the study of neurodegenerative diseases (such as Alzheimer's disease and schizophrenia). D-Isoleucine also acts as a non-classical D-amino acid, interferes with bacterial peptidoglycan synthesis, and inhibits the formation of Staphylococcus aureus biofilm, and has potential antibacterial application value[1][2].

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D-Isoleucine

D-イソロイシン 構造式

CAS 番号 : 319-78-8

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 44 在庫あり
Solution
10 mM * 1 mL in Water USD 44 在庫あり
Solid
25 mg $40 在庫あり
50 mg $65 在庫あり
100 mg $100 在庫あり
250 mg $160 在庫あり
1 g $300 在庫あり
5 g $750 在庫あり
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Other Forms of D-Isoleucine:

D-イソロイシン 関連抗体

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製品説明

D-Isoleucine is a selective competitive activator of the Asc-1 antiporter (Ki=0.98 mM). D-Isoleucine promotes the release of D-serine and glycine by binding to the Asc-1 protein on the neuronal cell membrane, and enhances NMDA receptor-dependent synaptic plasticity. D-Isoleucine can be used in the study of neurodegenerative diseases (such as Alzheimer's disease and schizophrenia). D-Isoleucine also acts as a non-classical D-amino acid, interferes with bacterial peptidoglycan synthesis, and inhibits the formation of Staphylococcus aureus biofilm, and has potential antibacterial application value[1][2].

体外実験

D-Isoleucine (1 mM, 2 mM; 15 min) significantly enhances LTP in hippocampal slices and promotes D-serine release from neurons via activation of Asc-1, which is dependent on NMDA receptors[1]. D-Isoleucine can be identified in the supernatant of Staphylococcus aureus grown in RPMI medium, and can be further used to track the amino acid metabolic footprint of the bacteria[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

D-イソロイシン 関連抗体
分子量

131.18

分子式

C6H13NO2
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

CC[C@@H](C)[C@@H](N)C(O)=O
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

H2O : 5.56 mg/mL (42.39 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.6234 mL 38.1170 mL 76.2340 mL
5 mM 1.5247 mL 7.6234 mL 15.2468 mL
10 mM 0.7623 mL 3.8117 mL 7.6234 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

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In Vivo Dissolution Calculator
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純度とドキュメンテーション

純度: 99.83%

COA (246 KB) HNMR (178 KB) RP-HPLC (241 KB) MS (81 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 7.6234 mL 38.1170 mL 76.2340 mL 190.5851 mL
5 mM 1.5247 mL 7.6234 mL 15.2468 mL 38.1170 mL
10 mM 0.7623 mL 3.8117 mL 7.6234 mL 19.0585 mL
15 mM 0.5082 mL 2.5411 mL 5.0823 mL 12.7057 mL
20 mM 0.3812 mL 1.9059 mL 3.8117 mL 9.5293 mL
25 mM 0.3049 mL 1.5247 mL 3.0494 mL 7.6234 mL
30 mM 0.2541 mL 1.2706 mL 2.5411 mL 6.3528 mL
40 mM 0.1906 mL 0.9529 mL 1.9059 mL 4.7646 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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D-Isoleucine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-Isoleucine319-78-8(R)-IsoleucineASCTAlanine Serine Cysteine TransportersInhibitorinhibitorinhibit

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