1. Apoptosis
  2. Apoptosis
  3. DC_AC50


Cat. No.: HY-107636
Handling Instructions

DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance.

For research use only. We do not sell to patients.

DC_AC50 Chemical Structure

DC_AC50 Chemical Structure

CAS No. : 497061-48-0

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DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance[1].

In Vitro

DC_AC50 exhibits IC50 values of 9.88 μM, 12.57 μM, 5.96 μM and 6.68 μM in Canine Abrams, Canine D1, human HOS and human MG63) cells, respectively[1].
DC_AC50 (0-10 μM)-treated cells are significantly less mitotically active, as demonstrated by decreased expression of phospho-histone H3 and cell cycle analysis[1].
DC_AC50 (10 μM) potentiates carboplatin-induced apoptosis in OSA cells and decreasesclonogenic survival[1].
DC_AC50 induces cell cycle arrest at both the 3 and 10 μM doses and DC_AC50 induces increase S phase cells dose-independently[1].
DC_AC50 (3 μM) inhibits the migration and of canine and human OSA cells[1].
DC_AC50 (2.5-10 μM) is highly efficient at inhibiting cancer cell proliferation (human lung cancer H1299 cells, leukaemia cancer K562 cells, breast cancer MDA-MB-231 cells and head and neck cancer 212LN cells) in a dose-dependent manner. DC_AC50 fails to exhibit any notable inhibition of the cell proliferation of human normal epithelial lung BEAS-2B cells or breast MCF-10A cells as control cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Canine OSA (Abrams, D1 and human OSA (HOS, MG63) cells.
Concentration: 0-10 μM.
Incubation Time: 72 h.
Result: Dose-dependently decreased viability of OSA cells.

Apoptosis Analysis[1]

Cell Line: Abrams and HOS cells.
Concentration: 1, 3 and 10 μM (10 μM Carboplatin).
Incubation Time: 24 h.
Result: Potentiated carboplatin-induced apoptosis.
Molecular Weight







Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

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