2. Apoptosis Metabolic Enzyme/Protease
  3. Drug Metabolite Apoptosis
  4. Desethylamiodarone

Desethylamiodarone  (Synonyms: N-Deethylamiodarone; LB 33020)

Cat. No.: HY-122423
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Desethylamiodarone (N-Deethylamiodarone) is the major metabolite of antiarrhythmic compound Amiodarone (HY-14187). Desethylamiodarone has antiarrhythmic activity. Desethylamiodaron also induces cancer cell apoptosis.

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Desethylamiodarone

Desethylamiodarone 화학구조

CAS No. : 83409-32-9

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Other In-stock Forms of Desethylamiodarone:

Desethylamiodarone Related Antibodies

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제품 설명

Desethylamiodarone (N-Deethylamiodarone) is the major metabolite of antiarrhythmic compound Amiodarone (HY-14187). Desethylamiodarone has antiarrhythmic activity. Desethylamiodaron also induces cancer cell apoptosis[1][2].

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
33 1
Compound: 4, dE-Ami
Antagonist activity at rat TAAR1 expressed in HEK293 cells assessed as intracellular cAMP level
Antagonist activity at rat TAAR1 expressed in HEK293 cells assessed as intracellular cAMP level
[PMID: 18752950]
LLC-PK1 IC50
15.4 3
Compound: Desethylamiodarone
TP_TRANSPORTER: inhibition of Daunorubicin transepithelial transport (basal to apical) (Daunorubicin: 0.035 uM) in MDR1-expressing LLC-PK1 cells
TP_TRANSPORTER: inhibition of Daunorubicin transepithelial transport (basal to apical) (Daunorubicin: 0.035 uM) in MDR1-expressing LLC-PK1 cells
[PMID: 11231118]
LLC-PK1 IC50
25.2 3
Compound: Desethylamiodarone
TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 0.025 uM) in MDR1-expressing LLC-PK1 cells
TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 0.025 uM) in MDR1-expressing LLC-PK1 cells
[PMID: 11231118]
HEK293 EC50
33 1
Compound: 4, dE-Ami
Antagonist activity at rat TAAR1 expressed in HEK293 cells assessed as intracellular cAMP level
Antagonist activity at rat TAAR1 expressed in HEK293 cells assessed as intracellular cAMP level
[PMID: 18752950]
LLC-PK1 IC50
15.4 3
Compound: Desethylamiodarone
TP_TRANSPORTER: inhibition of Daunorubicin transepithelial transport (basal to apical) (Daunorubicin: 0.035 uM) in MDR1-expressing LLC-PK1 cells
TP_TRANSPORTER: inhibition of Daunorubicin transepithelial transport (basal to apical) (Daunorubicin: 0.035 uM) in MDR1-expressing LLC-PK1 cells
[PMID: 11231118]
LLC-PK1 IC50
25.2 3
Compound: Desethylamiodarone
TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 0.025 uM) in MDR1-expressing LLC-PK1 cells
TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 0.025 uM) in MDR1-expressing LLC-PK1 cells
[PMID: 11231118]
분자량

617.26

화학식

C23H25I2NO3
CAS No.
SMILES

O=C(C1=CC(I)=C(C(I)=C1)OCCNCC)C2=C(OC3=CC=CC=C23)CCCC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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Desethylamiodarone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Desethylamiodarone83409-32-9N-Deethylamiodarone LB 33020LB33020LB 33020LB-33020Drug MetaboliteApoptosisantiarrhythmicAmiodaroneInhibitorinhibitorinhibit

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Desethylamiodarone
Cat. No.:
HY-122423
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