83409-32-9
Chemical Structure
Desethylamiodarone
Synonym(s): N-Desethylamiodarone; LB 33020
- CAS No.: 83409-32-9
- Formula:C23H25I2NO3
- Molecular Weight:617.26
IUPAC Name: (2-butylbenzofuran-3-yl)(4-(2-(ethylamino)ethoxy)-3,5-diiodophenyl)methanone
InChIKey: VXOKDLACQICQFA-UHFFFAOYSA-N
SMILES: O=C(C1=CC(I)=C(C(I)=C1)OCCNCC)C2=C(OC3=CC=CC=C23)CCCC
Biological Activity: Desethylamiodarone (N-Desethylamiodarone; LB 33020) is the major active metabolite of Amiodarone (HY-14187) generated via CYP3A4 metabolism. Desethylamiodarone downregulates p‑Akt, p‑Bad and Bcl‑2, upregulates Bax, promotes mitochondrial release of cytochrome c, activates caspase‑3 and cleaves PARP‑1, thereby inducing cell cycle arrest and apoptosis. Desethylamiodarone can be used in cervical cancer-related research[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Desethylamiodarone | Desethylamiodarone (N-Desethylamiodarone; LB 33020) is the major active metabolite of Amiodarone (HY-14187) generated via CYP3A4 metabolism. Desethylamiodarone downregulates p‑Akt, p‑Bad and Bcl‑2, upregulates Bax, promotes mitochondrial release of cytochrome c, activates caspase‑3 and cleaves PARP‑1, thereby inducing cell cycle arrest and apoptosis. Desethylamiodarone can be used in cervical cancer-related research. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Bognar Z, et al. Amiodarone's major metabolite, desethylamiodarone, induces apoptosis in human cervical cancer cells. Canadian journal of physiology and pharmacology. 2018 Oct;96(10):1004-1011.
- [2]. Beddows SA, et al. Cytotoxic effects of amiodarone and desethylamiodarone on human thyrocytes. Biochemical pharmacology. 1989 Dec 15;38(24):4397-403.
- [3]. Banach M, et al. Amiodarone Enhances Anticonvulsive Effect of Oxcarbazepine and Pregabalin in the Mouse Maximal Electroshock Model. International journal of molecular sciences. 2021 Jan 21;22(3):1041.
Keywords
