2. Metabolic Enzyme/Protease
  3. NADPH Oxidase
  4. Diapocynin

Diapocynin  (Synonyms: Dehydrodiacetovanillone)

Cat. No.: HY-121097 Purity: 99.0%
COA
SDS
Handling Instructions Technical Support

Diapocynin (Dehydrodiacetovanillone), a dimeric derivative of Apocynin, is an orally active NADPH oxidase inhibitor. Diapocynin has anti-inflammatory, neuroprotection and antioxidant activities.

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Diapocynin

Diapocynin 화학구조

CAS No. : 29799-22-2

사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg   견적 받기  
10 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

Diapocynin Related Antibodies

Top Publications Citing Use of Products

View All NADPH Oxidase Isoform Specific Products:

View All Isoforms
NOX1 NOX2 NOX4 NOX5 DUOX1

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

Diapocynin (Dehydrodiacetovanillone), a dimeric derivative of Apocynin, is an orally active NADPH oxidase inhibitor. Diapocynin has anti-inflammatory, neuroprotection and antioxidant activities[1].

In Vivo

Diapocynin (300 mg/kg; p.o.; every 12 hours for 72 hours) significantly rescues DFP-induced motor impairment, attenuates epileptiform spiking during the first 72h post-DFP. Diapocynin significantly reduces DFP-induced reactive astrogliosis, neurodegeneration, GP91phox, glutathiolated protein, serum nitrite, or pro-inflammatory cytokines and chemokines such as interleukins (IL) IL-1α, IL-6, IL-2, IL-17A, Leptin, IP-10 in the hippocampus[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats (200 g; 7-8 weeks old) injected with Diisopropylfluorophosphate (DFP)[1]
Dosage: 300 mg/kg
Administration: p.o.; every 12 hours for 72 hours
Result: Significantly rescued DFP-induced motor impairment.
분자량

330.33

화학식

C18H18O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC1=CC(C(C)=O)=CC(C2=C(O)C(OC)=CC(C(C)=O)=C2)=C1O
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

용액&용해도
In Vitro: 

DMSO : 5 mg/mL (15.14 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0273 mL 15.1364 mL 30.2728 mL
5 mM 0.6055 mL 3.0273 mL 6.0546 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 0.5 mg/mL (1.51 mM); Clear solution

    This protocol yields a clear solution of ≥ 0.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (5.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서

Purity: 99.0%

SDS (458 KB)

COA (252 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0273 mL 15.1364 mL 30.2728 mL 75.6819 mL
5 mM 0.6055 mL 3.0273 mL 6.0546 mL 15.1364 mL
10 mM 0.3027 mL 1.5136 mL 3.0273 mL 7.5682 mL
15 mM 0.2018 mL 1.0091 mL 2.0182 mL 5.0455 mL
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Diapocynin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diapocynin29799-22-2DehydrodiacetovanilloneNADPH OxidaseNOXNADPH oxidase inhibitordimericApocyninorally activeanti-inflammatoryneuroprotectionantioxidantInhibitorinhibitorinhibit

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상품명:
Diapocynin
Cat. No.:
HY-121097
수량:
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SAFETY DATA SHEET (SDS)

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