2. Vitamin D Related/Nuclear Receptor Apoptosis
  3. Nuclear Hormone Receptor 4A/NR4A Apoptosis
  4. DIM-C-pPhOH

DIM-C-pPhOH is a nuclear receptor 4A1 (NR4A1) antagonist. DIM-C-pPhOH inhibits cancer cell growth and mTOR signaling, induce apoptosis and cellular stress. DIM-C-pPhOH reduces cell proliferation with IC50 values of 13.6 μM and 13.0 μM for ACHN cells and 786-O cells, respectively.

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CAS 番号 : 151358-47-3

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 82 在庫あり
Solution
10 mM * 1 mL in DMSO USD 82 在庫あり
Solid
1 mg $35 在庫あり
5 mg $75 在庫あり
10 mg $95 在庫あり
25 mg $190 在庫あり
50 mg $290 在庫あり
100 mg $490 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

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カスタマーレビュー

Based on 9 publication(s) in Google Scholar

DIM-C-pPhOH 関連抗体

Top Publications Citing Use of Products

    DIM-C-pPhOH purchased from MedChemExpress. Usage Cited in: Transl Neurodegener. 2025 Jun 4;14(1):29.  [Abstract]

    The recognition index for the new object recorded over a 24 h period in the NOR test (n = 6–8 animals/group). DIM-C-pPhOH (DIM-C, 50 mg/kg; i.p.; once daily for 1 week) treatment substantially increased the cognitive discrimination index of C57BL/6J mice compared to the AAV-siYAP1 group.

    DIM-C-pPhOH purchased from MedChemExpress. Usage Cited in: Transl Neurodegener. 2025 Jun 4;14(1):29.  [Abstract]

    Golgi staining and quantitation of spine number in the dentate gyrus of the hippocampus (n = 5 animals/group).The results showed that DIM-C-pPhOH (DIM-C, 50 mg/kg; i.p.; once daily for 1 week) alleviated YAP1 deletion-triggered dendritic spine loss in C57BL/6J mice.

    DIM-C-pPhOH purchased from MedChemExpress. Usage Cited in: Transl Neurodegener. 2025 Jun 4;14(1):29.  [Abstract]

    DIM-C-pPhOH (DIM-C, 50 mg/kg; i.p.; once daily for 1 week) partially reversed YAP1-induced reduction of synapse-related proteins (PSD95 and synaptophysin) in the hippocampus of C57BL/6J mice via inhibiting Nr4a1.

    DIM-C-pPhOH purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Sep 10:S2090-1232(25)00701-5.  [Abstract]

    Echocardiography analysis of representative B-model sonography of different groups of mice on the 14th day after Sham and MI. The results demonstrated that NR4a1 inhibition by DIM-C-pPhOH (DIM-C; 50 mg/kg; i.p.) counteracted the detrimental effects of SAMHD1 overexpression on post-MI cardiac function.

    DIM-C-pPhOH purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Sep 10:S2090-1232(25)00701-5.  [Abstract]

    mRNA levels of Arg1 and Nos2 in heart tissues of different groups of mice on day 3 after Sham and MI (n=6). The results revealed that DIM-C-pPhOH (DIM-C; 50 mg/kg; i.p.) treatment reversed the SAMHD1 overexpression-induced suppression of the cardiac reparative factor Arg1 and reversed the upregulation of the proinflammatory factor Nos2.

    Nuclear Hormone Receptor 4A/NR4A アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Nur77/NR4A1 Nurr1/NR4A2

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    DIM-C-pPhOH is a nuclear receptor 4A1 (NR4A1) antagonist. DIM-C-pPhOH inhibits cancer cell growth and mTOR signaling, induce apoptosis and cellular stress. DIM-C-pPhOH reduces cell proliferation with IC50 values of 13.6 μM and 13.0 μM for ACHN cells and 786-O cells, respectively[1].

    IC50 & Target

    Nur77/NR4A1

     

    体外実験

    DIM-C-pPhOH (7.5-20 μM; 24 hours; ACHN and 786-O cells) treatment significantly decreases cell proliferation[1].
    DIM-C-pPhOH (20 μM; 24 hours; ACHN and 786-O cells) treatment induces Annexin V staining in ACHN and 786-O cells, confirming that DIM-C-pPhOH induce apoptosis, and also induces cleavage of caspases 7 and 8[1].
    DIM-C-pPhOH (15-20 μM; 24 hours; ACHN and 786-O cells) treatment inhibits NR4A1-regulated expression of survivin, bcl-2 and EGFR in ACHN and 786-O cells. And also induces sestrin 2, activates AMPKα and inhibits activation of mTOR and downstream kinases[1].
    DIM-C-pPhOH decreases expression of β1-integrin protein and mRNA and β1-integrin-dependent responses in MCF7, MDA-MB-231, and SKBR3 cells and also inhibits migration of the latter two cell lines[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    DIM-C-pPhOH 関連抗体

    Cell Proliferation Assay[1]

    Cell Line: ACHN and 786-O cells
    Concentration: 7.5 μM, 15 μM, 20 μM
    Incubation Time: 24 hours
    Result: Significantly decreased cell proliferation.

    Apoptosis Analysis[1]

    Cell Line: ACHN and 786-O cells
    Concentration: 20 μM
    Incubation Time: 24 hours
    Result: Induced apoptosis in ACHN and 786-O cells.

    Western Blot Analysis[1]

    Cell Line: ACHN and 786-O cells
    Concentration: 15 μM, 20 μM
    Incubation Time: 24 hours
    Result: Inhibited NR4A1-regulated expression of survivin, bcl-2 and EGFR in ACHN and 786-O cells. And also induced sestrin 2, activated AMPKα and inhibited activation of mTOR and downstream kinases.
    体内実験

    DIM-C-pPhOH (30 mg/kg; oral gavage; daily; for 50 days; male athymic nude mice) treatment results in a significant inhibition of tumor growth[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male athymic nude mice (aged 6-7 weeks) injected with ACHN cells[1]
    Dosage: 30 mg/kg/day
    Administration: Oral gavage; daily; for 50 days
    Result: Resulted in a significant inhibition of tumor growth.
    分子量

    338.40

    分子式

    C23H18N2O
    CAS 番号
    Appearance

    Solid

    Color

    Off-white to pink

    SMILES

    OC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 125 mg/mL (369.39 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.9551 mL 14.7754 mL 29.5508 mL
    5 mM 0.5910 mL 2.9551 mL 5.9102 mL
    10 mM 0.2955 mL 1.4775 mL 2.9551 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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    一般には略語で表示されます：C1V1 = C2V2

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    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (6.15 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (6.15 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
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    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 98.88%

    COA (256 KB) HNMR (253 KB) LCMS (88 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.9551 mL 14.7754 mL 29.5508 mL 73.8771 mL
    5 mM 0.5910 mL 2.9551 mL 5.9102 mL 14.7754 mL
    10 mM 0.2955 mL 1.4775 mL 2.9551 mL 7.3877 mL
    15 mM 0.1970 mL 0.9850 mL 1.9701 mL 4.9251 mL
    20 mM 0.1478 mL 0.7388 mL 1.4775 mL 3.6939 mL
    25 mM 0.1182 mL 0.5910 mL 1.1820 mL 2.9551 mL
    30 mM 0.0985 mL 0.4925 mL 0.9850 mL 2.4626 mL
    40 mM 0.0739 mL 0.3694 mL 0.7388 mL 1.8469 mL
    50 mM 0.0591 mL 0.2955 mL 0.5910 mL 1.4775 mL
    60 mM 0.0493 mL 0.2463 mL 0.4925 mL 1.2313 mL
    80 mM 0.0369 mL 0.1847 mL 0.3694 mL 0.9235 mL
    100 mM 0.0296 mL 0.1478 mL 0.2955 mL 0.7388 mL
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    DIM-C-pPhOH Related Classifications

    • Molarity Calculator

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    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
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    Keywords:

    DIM-C-pPhOH151358-47-3Nuclear Hormone Receptor 4A/NR4AApoptosisNuclear Hormone Receptor 4ANerve Growth Factor IB-like ReceptormTORsignalingapoptosisstresscancerxenograftsnuclear receptorβ1-integrinInhibitorinhibitorinhibit

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    製品名:
    DIM-C-pPhOH
    製品番号:
    HY-112055
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