2. Disease Areas
  3. Musculoskeletal Disease
  4. Muscle Disease
  5. Muscle Relaxation and Spasm

Muscle Relaxation and Spasm

Muscle relaxation involves the release of muscle tension through techniques like progressive muscle relaxation, resulting in reduced heart rate, normalized blood flow, slower respiration, and increased alpha brain waves. Muscle spasm refers to involuntary muscle contractions that restrict movement, commonly affecting large muscle groups such as the quadriceps, and may lead to joint displacement.

References:

Muscle Relaxation and Spasm (12):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-19699
    1-Naphthylacetamide 86-86-2
    1-Naphthylacetamide is an orally active nonsteroidal anti-inflammatory agent (NAIA) and also an indole-type auxin plant growth regulator. 1-Naphthylacetamide inhibits inflammatory response-related pathways and modulates plant hormone signaling, exhibiting anti-inflammatory, local anesthetic, antispasmodic, analgesic, and diuretic activities. 1-Naphthylacetamide promotes plant cell expansion, differentiation, and fruit enlargement. Additionally, 1-Naphthylacetamide induces central nervous system (CNS) depression in mice, characterized by reduced spontaneous activity, decreased irritability, decreased muscle tone, and attenuated ear-cuff reflex, ipsilateral flexor reflex, and corneal reflex[1][2].
    1-Naphthylacetamide
  • HY-N0340
    Scopolamine butylbromide 149-64-4 99.97%
    Scopolamine butylbromide (Hyoscine butylbromide) is an orally active anticholinergic agent and spasmolytic. Scopolamine butylbromide binds with high affinity to rat cardiac M2 (Ki 83 nmol/L), hM2 (Ki 233 nmol/L), rat intestinal M3 (Ki 290 nmol/L) and hM3 (Ki 643 nmol/L) muscarinic receptors. Scopolamine butylbromide exerts a dose-dependent antagonistic effect on Carbachol-induced gastrointestinal smooth muscle spasm. Scopolamine butylbromide can be used for the research of abdominal colic and pain associated with gastrointestinal spasm, functional abdominal pain, chronic gastropathy and gastric ulcer.
    Scopolamine butylbromide
  • HY-145512
    N-(α-Linolenoyl) tyrosine 259143-19-6 98.98%
    N-(α-Linolenoyl) tyrosine (NLT) is a dopaminergic agonist capable of crossing the blood-brain barrier. N-(α-Linolenoyl) tyrosine increases the level, turnover rate and release amount of dopamine in the striatum. N-(α-Linolenoyl) tyrosine modulates rotational behavior in a rat model with unilateral striatal injury and alleviates excessive blinking symptoms in models induced by dopamine-depleting agents. N-(α-Linolenoyl) tyrosine can be used for research on Parkinson's disease and idiopathic blepharospasm.
    N-(α-Linolenoyl) tyrosine
  • HY-43934
    Tiropramide hydrochloride 53567-47-8
    Tiropramide (CR 605) hydrochloride is a tyrosine derivative with antispastic properties. Tiropramide hydrochloride inhibits phosphodiesterase activity involved in cAMP catabolism in rabbit colon homogenates. Tiropramide hydrochloride relaxes smooth muscle in rabbit isolated colon. Tiropramide hydrochloride can be used for the research of irritable colon and biliary dyskinesia.
    Tiropramide hydrochloride
  • HY-116755
    Tiropramide 55837-29-1
    Tiropramide (CR 605) is a tyrosine derivative with antispastic properties. Tiropramide hydrochloride inhibits phosphodiesterase activity involved in cAMP catabolism in rabbit colon homogenates. Tiropramide relaxes smooth muscle in rabbit isolated colon. Tiropramide can be used for the research of irritable colon and biliary dyskinesia.
    Tiropramide
  • HY-114833
    Bunolol 27591-01-1
    Bunolol ((Rac)-Bunolol) is a β-adrenergic receptor blocker. Bunolol antagonizes the β-receptor agonist activity induced by Isoproterenol (HY-B0468) and Dichloroisoproterenol. Bunolol reduces the heart rate and mean blood pressure of anesthetized dogs. Bunolol decreases spontaneous motor activity and Amphetamine-induced hyperactivity in rats, potentiates Pentobarbital-induced hypnosis in mice, and protects rats from extensor tonic convulsions induced by maximal electroshock.
    Bunolol
  • HY-121554
    Kojic amine 68642-64-8
    Kojic amine is an orally active γ-aminobutyric acid (GABA) analog. Kojic amine acts as a GABA mimic that inhibits sodium-independent [3H]GABA binding to rat brain cell membranes. Kojic amine reduces flexor spasms in chronic spinal rat and cat models. Kojic amine prevents tonic extensor convulsions in mice. Kojic amine produces a transient, dose-dependent analgesic effect in the mouse hot-plate test. Kojic amine can be used in research related to skeletal muscle spasm, epilepsy and analgesia[1][2]
    Kojic amine
  • HY-19685A
    Sintropium bromide 79467-19-9
    Sintropium bromide is a mAChR antagonist with anticholinergic effects. Sintropium bromide can be used for pain and spasm research.
    Sintropium bromide
  • HY-N17187
    2,4,6,1'-Tetra-O-acetyl-3',6'-di-O-feruloylsucrose 173614-59-0
    2,4,6,1'-Tetra-O-acetyl-3',6'-di-O-feruloylsucrose (Compound 2) is a phenylpropanoid glycoside that can be found in chinese folk medicine “San Leng” (Sparganium stoloniferum Buch.-Hamil.). San Leng can be used for emmenagogue, galactagogue, and antispasmodic applications.
    2,4,6,1'-Tetra-O-acetyl-3',6'-di-O-feruloylsucrose
  • HY-W742955
    Pargeverine hydrochloride 2765-97-1
    Pargeverine hydrochloride is an antispasmodic opioid alkaloid. Pargeverine hydrochloride has a moderate and non-selective blockade of muscarinic cholinergic fibers. Pargeverine hydrochloride can be used in the research of painful spasms.
    Pargeverine hydrochloride
  • HY-W748379
    Fenyramidol 553-69-5
    Fenyramidol is an Aminopyridine derivative. Fenyramidol can be used as a moderately potent, non-narcotic muscle relaxant with concomitant analgesic activity.
    Fenyramidol
  • HY-B0007A
    (S)-Baclofen hydrochloride 63701-56-4
    (S)-Baclofen hydrochloride is a GABAB receptor agonist that crosses the blood-brain barrier and is orally active, with IC50 values ​​of 1.77 μM for GABAB and 1564 μM for GABAA. (S)-Baclofen hydrochloride can be used in research on muscle disorders such as spasticity.
    (S)-Baclofen hydrochloride