2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Kojic amine

Kojic amine is an orally active γ-aminobutyric acid (GABA) analog. Kojic amine acts as a GABA mimic that inhibits sodium-independent [3H]GABA binding to rat brain cell membranes. Kojic amine reduces flexor spasms in chronic spinal rat and cat models. Kojic amine prevents tonic extensor convulsions in mice. Kojic amine produces a transient, dose-dependent analgesic effect in the mouse hot-plate test. Kojic amine can be used in research related to skeletal muscle spasm, epilepsy and analgesia[1][2]

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Kojic amine

Kojic amine Chemical Structure

CAS No. : 68642-64-8

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Kojic amine Related Antibodies

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Description

Kojic amine is an orally active γ-aminobutyric acid (GABA) analog. Kojic amine acts as a GABA mimic that inhibits sodium-independent [3H]GABA binding to rat brain cell membranes. Kojic amine reduces flexor spasms in chronic spinal rat and cat models. Kojic amine prevents tonic extensor convulsions in mice. Kojic amine produces a transient, dose-dependent analgesic effect in the mouse hot-plate test. Kojic amine can be used in research related to skeletal muscle spasm, epilepsy and analgesia[1][2]

In Vitro

Kojic amine (Compound 3) potently and specifically inhibits the Na+-independent binding of [3H]GABA to rat brain cell membranes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Kojic amine Related Antibodies
In Vivo

kojic amine i.v.(i.v.) reduces flexor reflex spasm in rats with chronic spinal cord injury by 70%, with an ED70 of 8 mg/kg for intravenous delivery[1].
Kojic amine (i.v., oral administration; cumulative dosing) reduces flexor reflex spasm in chronic spinal cats by 70%, with an intravenous ED70 of 2.2 mg/kg and an oral ED70 of 4 mg/kg[1].
Kojic amine (15-128 mg/kg; i.g.; single dose) prevents 3-mercaptopropionic acid-induced tonic extensor convulsions in 50% of mice at an oral ED50 of 15 mg/kg[1].
Kojic amine (8.2-15.7 mg/kg; i.p.; single administration) produces dose-dependent, short-acting analgesic effects in the mouse hot-plate test at 48°C and 55°C, with ED50 values of 9.2 mg/kg and 13.8 mg/kg, respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Robidoux Swiss (male, 18-22 g, 3-mercaptopropionic acid-induced convulsions)[1]
Dosage: 15 mg/kg (seizure prevention ED50); 128 mg/kg (acute oral non-lethal)
Administration: p.o.; single dose (30 mins prior to convulsion induction)
Result: Prevented tonic extensor seizures in 50% of mice (ED50) challenged with 3-mercaptopropionic acid.
Allowed all mice to survive an acute oral dose of 128 mg/kg.
Animal Model: albino Swiss CD-1 (male, 18-24 g)[2]
Dosage: 8.2-15.7 mg/kg
Administration: i.p.; single dose
Result: Produced dose-dependent, short-acting analgesic effects in the mouse hot-plate test at 48°C and 55°C, with ED50 values of 9.2 mg/kg and 13.8 mg/kg, respectively.
Molecular Weight

141.13

Formula

C6H7NO3
CAS No.
SMILES

O=C1C=C(OC=C1O)CN
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Storage

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Purity & Documentation
References
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Kojic amine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Kojic amine68642-64-8GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGABA receptor3-mercaptopropionic acidrat brain membranescerebellar Purkinje cellGABA_B receptormiceskeletal muscle relaxantGABA_A receptorchronic spinal ratchronic spinal catskeletal muscle spasmepilepsy and analgesiaInhibitorinhibitorinhibit

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