Bunolol

Bunolol (0.1 mg/kg; i.v.; single dose) exhibits potent β-adrenergic blocking activity in barbiturate-anesthetized mongrel dogs, achieving complete blockade of isoproterenol-induced cardiac effects at an intravenous dose of 0.1 mg/kg^[1].
Bunolol (0.1-3.2 mg/kg; i.v.; cumulative increments at 10-minute intervals; 1-3 mg/kg; i.v.; single dose, 15 minutes before alprenolol) does not significantly alter pulmonary resistance in healthy anesthetized dogs, but a 3 mg/kg dose blocks the resistance-lowering effect of low-dose alprenolol^[2].
Bunolol (1 mg/kg; i.p.; single dose) does not exhibit inherent sedative or hypnotic effects in normal albino mice, but significantly potentiates pentobarbitone-induced hypnosis at 1 mg/kg^[3].
Bunolol (10 mg/kg; i.p.; single dose) provides 20% protection against maximal electroshock-induced seizures in albino rats, reduces mean extensor tonic spasm duration to 2.6 seconds, and increases mean stupor duration to 27.0 minutes without causing mortality^[3].