27591-01-1
Chemical Structure
Bunolol
Synonym(s): (Rac)-Bunolol; dl-Bunolol
- No. CAS: 27591-01-1
- Formula:C17H25NO3
- Molecular Weight:291.39
IUPAC Name: 5-(3-(tert-butylamino)-2-hydroxypropoxy)-3,4-dihydronaphthalen-1(2H)-one
InChIKey: IXHBTMCLRNMKHZ-UHFFFAOYSA-N
SMILES: O=C1C=2C=CC=C(OCC(O)CNC(C)(C)C)C2CCC1
Biological Activity: Bunolol ((Rac)-Bunolol) is a β-adrenergic receptor blocker. Bunolol antagonizes the β-receptor agonist activity induced by Isoproterenol (HY-B0468) and Dichloroisoproterenol. Bunolol reduces the heart rate and mean blood pressure of anesthetized dogs. Bunolol decreases spontaneous motor activity and Amphetamine-induced hyperactivity in rats, potentiates Pentobarbital-induced hypnosis in mice, and protects rats from extensor tonic convulsions induced by maximal electroshock[1][2][3].
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Bunolol | Bunolol ((Rac)-Bunolol) is a β-adrenergic receptor blocker. Bunolol antagonizes the β-receptor agonist activity induced by Isoproterenol (HY-B0468) and Dichloroisoproterenol. Bunolol reduces the heart rate and mean blood pressure of anesthetized dogs. Bunolol decreases spontaneous motor activity and Amphetamine-induced hyperactivity in rats, potentiates Pentobarbital-induced hypnosis in mice, and protects rats from extensor tonic convulsions induced by maximal electroshock. | |||||||||||||||||||||
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References
- [1]. Schwender C F, et al. Derivatives of 3, 4-dihydro-1 (2H)-naphthalenone as. beta.-adrenergic blocking agents. 3. Carbonyl-containing analogs of bunolol[J]. Journal of Medicinal Chemistry, 1973, 16(5): 585-588.
- [2]. Giles RE, et al. Effects of alprenolol, bunolol and propranolol on pulmonary resistance in the anaesthetized dog. Eur J Pharmacol. 1971 Oct;16(2):155-63. [Content Brief]
- [3]. Khanna N K, et al. Neuropharmacological Actions of two New Adrenergic Beta-Receptor Antagonists, Bunolol and H 64/52[J]. The Japanese Journal of Pharmacology, 1972, 22(2): 262-264.
