Tiropramide hydrochloride (Synonyms: CR 605 hydrochloride)

Cat. No.: HY-43934: Data Sheet
SDS
Handling Instructions
FAQs
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Tiropramide (CR 605) hydrochloride is a tyrosine derivative with antispastic properties. Tiropramide hydrochloride inhibits phosphodiesterase activity involved in cAMP catabolism in rabbit colon homogenates. Tiropramide hydrochloride relaxes smooth muscle in rabbit isolated colon. Tiropramide hydrochloride can be used for the research of irritable colon and biliary dyskinesia.

For research use only. We do not sell to patients.

Tiropramide hydrochloride Chemical Structure

CAS No. : 53567-47-8

Size	Stock	Quantity
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	Get quote
1 g	Get quote

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Other Forms of Tiropramide hydrochloride:

Tiropramide Get quote

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Tiropramide hydrochloride inhibits phosphodiesterase activity in rabbit colon homogenates and increases ATP- and Mg²⁺-dependent calcium binding to rabbit colon sarcoplasmic reticulum microsomal fractions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

504.10

Formula

C₂₈H₄₂ClN₃O₃

CAS No.

53567-47-8

Appearance

Solid

SMILES

O=C(C1=CC=CC=C1)NC(CC2=CC=C(C=C2)OCCN(CC)CC)C(N(CCC)CCC)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (247.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9837 mL	9.9187 mL	19.8373 mL
5 mM	0.3967 mL	1.9837 mL	3.9675 mL
10 mM	0.1984 mL	0.9919 mL	1.9837 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Data Sheet (269 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. Vidal y Plana RR, et al. Mechanism of smooth muscle relaxation by tiropramide. J Pharm Pharmacol. 1981;33(1):19-24. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9837 mL	9.9187 mL	19.8373 mL	49.5933 mL
	5 mM	0.3967 mL	1.9837 mL	3.9675 mL	9.9187 mL
	10 mM	0.1984 mL	0.9919 mL	1.9837 mL	4.9593 mL
	15 mM	0.1322 mL	0.6612 mL	1.3225 mL	3.3062 mL
	20 mM	0.0992 mL	0.4959 mL	0.9919 mL	2.4797 mL
	25 mM	0.0793 mL	0.3967 mL	0.7935 mL	1.9837 mL
	30 mM	0.0661 mL	0.3306 mL	0.6612 mL	1.6531 mL
	40 mM	0.0496 mL	0.2480 mL	0.4959 mL	1.2398 mL
	50 mM	0.0397 mL	0.1984 mL	0.3967 mL	0.9919 mL
	60 mM	0.0331 mL	0.1653 mL	0.3306 mL	0.8266 mL
	80 mM	0.0248 mL	0.1240 mL	0.2480 mL	0.6199 mL
	100 mM	0.0198 mL	0.0992 mL	0.1984 mL	0.4959 mL

Tiropramide hydrochloride Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tiropramide53567-47-8CR 605CR605CR-605Phosphodiesterase (PDE)ATPMg2+cAMP catabolismCa2+ bindingphosphodiesterase inhibitorcAMP concentrationsrabbit isolated colon smooth musclerabbit colon homogenatessarcoplasmic reticulum microsomal fractionphosphodiesterase activityInhibitorinhibitorinhibit

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