Tiropramide
Tiropramide (CR 605) is a tyrosine derivative with antispastic properties. Tiropramide hydrochloride inhibits phosphodiesterase activity involved in cAMP catabolism in rabbit colon homogenates. Tiropramide relaxes smooth muscle in rabbit isolated colon. Tiropramide can be used for the research of irritable colon and biliary dyskinesia.
For research use only. We do not sell to patients.
- CAS No.: 55837-29-1
- Formula: C28H41N3O3
- Molecular Weight:467.64
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Tiropramide inhibits phosphodiesterase activity in rabbit colon homogenates and increases ATP- and Mg2+-dependent calcium binding to rabbit colon sarcoplasmic reticulum microsomal fractions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 55837-29-1
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Molecular Weight 467.64
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Formula C28H41N3O3
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SMILES
O=C(C(CC1=CC=C(C=C1)OCCN(CC)CC)NC(C2=CC=CC=C2)=O)N(CCC)CCC
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Synonyms
CR 605
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Vidal y Plana RR, et al. Mechanism of smooth muscle relaxation by tiropramide. J Pharm Pharmacol. 1981;33(1):19-24. [Content Brief]
[2]. Soo Kyoung Baek, et al. Semi-micro high-performance liquid chromatographic analysis of tiropramide in human plasma using column-switching. J Pharm Biomed Anal. 2003 Feb 5;31(1):185-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tiropramide Related Classifications
HY-116755 Related Classifications
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