Tiropramide (Synonyms: CR 605)

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Tiropramide (CR 605) is a tyrosine derivative with antispastic properties. Tiropramide hydrochloride inhibits phosphodiesterase activity involved in cAMP catabolism in rabbit colon homogenates. Tiropramide relaxes smooth muscle in rabbit isolated colon. Tiropramide can be used for the research of irritable colon and biliary dyskinesia.

For research use only. We do not sell to patients.

Tiropramide Chemical Structure

CAS No. : 55837-29-1

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Other In-stock Forms of Tiropramide:

Tiropramide hydrochloride

Other Forms of Tiropramide:

Tiropramide hydrochloride In-stock
Tiropramide-d₅ Get quote

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View All Phosphodiesterase (PDE) Isoform Specific Products:

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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Purity & Documentation
References
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Description

In Vitro

Tiropramide inhibits phosphodiesterase activity in rabbit colon homogenates and increases ATP- and Mg²⁺-dependent calcium binding to rabbit colon sarcoplasmic reticulum microsomal fractions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

467.64

Formula

C₂₈H₄₁N₃O₃

CAS No.

55837-29-1

SMILES

O=C(C(CC1=CC=C(C=C1)OCCN(CC)CC)NC(C2=CC=CC=C2)=O)N(CCC)CCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Vidal y Plana RR, et al. Mechanism of smooth muscle relaxation by tiropramide. J Pharm Pharmacol. 1981;33(1):19-24. [Content Brief]

[2]. Soo Kyoung Baek, et al. Semi-micro high-performance liquid chromatographic analysis of tiropramide in human plasma using column-switching. J Pharm Biomed Anal. 2003 Feb 5;31(1):185-9. [Content Brief]

Tiropramide Related Classifications

Neurological Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tiropramide55837-29-1CR 605CR605CR-605Phosphodiesterase (PDE)ATPMg2+cAMP catabolismCa2+ bindingphosphodiesterase inhibitorcAMP concentrationsrabbit isolated colon smooth musclerabbit colon homogenatessarcoplasmic reticulum microsomal fractionphosphodiesterase activityInhibitorinhibitorinhibit

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