DMT-2'-O-MOE-rA(Bz) phosphoramidite

Name: DMT-2'-O-MOE-rA(Bz) phosphoramidite
Brand: MedChemExpress
SKU: HY-104017
Rating: 4.5 (0 reviews)

Cat. No.: HY-104017 Purity: 98.0%: Data Sheet
COA

SDS
Handling Instructions
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DMT-2'-O-MOE-rA(Bz) phosphoramidite is an adenine nucleoside analog. DMT-2'-O-MOE-rA(Bz) phosphoramidite can be used in research on oligonucleotide synthesis.

For research use only. We do not sell to patients.

DMT-2'-O-MOE-rA(Bz) phosphoramidite Chemical Structure

CAS No. : 251647-53-7

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250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
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5 g	In-stock	Estimated Time of Arrival: December 31
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Other Forms of DMT-2'-O-MOE-rA(Bz) phosphoramidite:

DMT-2'-O-MOE-rA(Bz) phosphoramidite (Standard) Get quote

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Purity & Documentation
References
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Description

DMT-2'-O-MOE-rA(Bz) phosphoramidite is an adenine nucleoside analog. DMT-2'-O-MOE-rA(Bz) phosphoramidite can be used in research on oligonucleotide synthesis^[1].

In Vitro

In oligonucleotide synthesis, DMT-2'-O-MOE-rA(Bz) phosphoramidite can be used to introduce 2'-O-methoxyethyl-modified adenine into oligonucleotide chains. This modification can enhance the double-strand stability of oligonucleotides, improve their resistance to nucleases, and exhibit relatively low toxicity.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

932.01

Formula

C₅₀H₅₈N₇O₉P

CAS No.

251647-53-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=CC=C1)NC2=NC=NC3=C2N=CN3[C@H]4[C@H](OCCOC)[C@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](COC(C5=CC=C(OC)C=C5)(C6=CC=CC=C6)C7=CC=C(OC)C=C7)O4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (214.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0729 mL	5.3647 mL	10.7295 mL
5 mM	0.2146 mL	1.0729 mL	2.1459 mL
10 mM	0.1073 mL	0.5365 mL	1.0729 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.0%

Select Batch:

Data Sheet (276 KB) SDS (393 KB)

COA (263 KB) HNMR (142 KB)

Handling Instructions (2659 KB)

References

[1]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0729 mL	5.3647 mL	10.7295 mL	26.8237 mL
	5 mM	0.2146 mL	1.0729 mL	2.1459 mL	5.3647 mL
	10 mM	0.1073 mL	0.5365 mL	1.0729 mL	2.6824 mL
	15 mM	0.0715 mL	0.3576 mL	0.7153 mL	1.7882 mL
	20 mM	0.0536 mL	0.2682 mL	0.5365 mL	1.3412 mL
	25 mM	0.0429 mL	0.2146 mL	0.4292 mL	1.0729 mL
	30 mM	0.0358 mL	0.1788 mL	0.3576 mL	0.8941 mL
	40 mM	0.0268 mL	0.1341 mL	0.2682 mL	0.6706 mL
	50 mM	0.0215 mL	0.1073 mL	0.2146 mL	0.5365 mL
	60 mM	0.0179 mL	0.0894 mL	0.1788 mL	0.4471 mL
	80 mM	0.0134 mL	0.0671 mL	0.1341 mL	0.3353 mL
	100 mM	0.0107 mL	0.0536 mL	0.1073 mL	0.2682 mL