2. Antibody-drug Conjugate/ADC Related
  3. Radionuclide-Drug Conjugates (RDCs)
  4. DOTATATE acetate

DOTATATE acetate  (Synonyms: Oxodotreotide acetate)

Art. -Nr.: HY-106244A Reinheit: 99.95%
COA
SDS
Handling Instructions Technical Support

DOTATATE acetate is a DOTA-conjugated peptide. DOTATATE acetate can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide research (PRRT). DOTATATE (acetate) can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

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Kundenspezifische Peptidsynthese

CAS. Nr. : 177943-89-4

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Based on 3 publication(s) in Google Scholar

Other Forms of DOTATATE acetate:

DOTATATE acetate Related Antibodies

Top Publications Citing Use of Products

    DOTATATE acetate purchased from MedChemExpress. Usage Cited in: J Nucl Med. 2024 Oct 1;65(10):1619-1625.  [Abstract]

    Total absorbed dose to cell nucleus for range of added activity concentrations of both 161Tb- and 177Lu-labeled DOTATATE (0-1.25 MBq/mL).

    DOTATATE acetate purchased from MedChemExpress. Usage Cited in: J Nucl Med. 2024 Oct 1;65(10):1619-1625.  [Abstract]

    Radiolabeled DOTATATE (1 MBq/mL) resulted in a higher absorbed dose than did radiolabeled DOTA-LM3, because of DOTATATE's higher Bmax and higher internalization.

    DOTATATE acetate purchased from MedChemExpress. Usage Cited in: J Nucl Med. 2024 Oct 1;65(10):1619-1625.  [Abstract]

    The nuclear dose-response data of both [177Lu]Lu- and [161Tb]Tb-DOTATATE (0-25 Gy) were best fitted with a linear model and could be fitted with a common, single curve.

    DOTATATE acetate purchased from MedChemExpress. Usage Cited in: J Nucl Med. 2024 Oct 1;65(10):1619-1625.  [Abstract]

    The saturation binding assay represented total binding and nonspecific binding for different added activity concentrations of [161Tb]Tb-DOTATATE (0-60 nM) with a fixed molar activity of 100 MBq/nmol.

    DOTATATE acetate purchased from MedChemExpress. Usage Cited in: J Nucl Med. 2024 Oct 1;65(10):1619-1625.  [Abstract]

    Clonogenic survival of CA20948 cells after treatment with [161Tb]Tb- and [177Lu]Lu-DOTATATE (0-1.5 MBq/mL) as a function of added activity concentration (MBq/mL).

    Alle Radionuclide-Drug Conjugates (RDCs) Isoform-spezifische Produkte anzeigen:

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    RDC Peptide RDC Antibody RDC Bifunctional Chelator RDC Linker Other

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    Beschreibung

    DOTATATE acetate is a DOTA-conjugated peptide. DOTATATE acetate can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide research (PRRT)[1][2][3][4]. DOTATATE (acetate) can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

    IC50 & Target

    RDC Peptide

     

    In Vivo

    177Lu-DOTATATE shows excellent antitumor effects in rats[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Klinische Studie
    Formel

    C65H90N14O19S2.xC2H4O2
    CAS. Nr.
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    {DOTA}-{d-Phe}-Cys-Tyr-{d-Trp}-Lys-Thr-Cys-Thr (Disulfide bridge:Cys2-Cys7)
    Sequence Shortening

    {DOTA}-{d-Phe}-CY-{d-Trp}-KTCT (Disulfide bridge:Cys2-Cys7)
    Versand

    Room temperature in continental US; may vary elsewhere.
    Speicherung

    Sealed storage, away from moisture and light, under nitrogen

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

    Lösungsmittel & Löslichkeit
    In Vitro: 

    DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 8.33 mg/mL (ultrasonic and warming and heat to 60°C)

    • Molaritätsrechner

    • Verdünnungsrechner

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 11.11 mg/mL; Clear solution; Need ultrasonic and warming and heat to 60°C

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Reinheit & Dokumentation

    Purity: 99.95%

    SDS (393 KB)

    COA (263 KB) LCMS (93 KB)

    Handling Instructions (2659 KB)
    Verweise
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    • If you have published this work, please enter the PubMed ID.
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    DOTATATE acetate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    DOTATATE177943-89-4OxodotreotideRadionuclide-Drug Conjugates (RDCs)radionuclidespositronemissiontomographyPETimagingpeptidereceptorradionuclidetherapyPRRTtumorInhibitorinhibitorinhibit

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