2. Antibody-drug Conjugate/ADC Related
  3. Radionuclide-Drug Conjugates (RDCs)
  4. DOTATATE

DOTATATE is a DOTA-conjugated peptide. DOTATATE can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide research (PRRT). DOTATATE can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

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Síntesis de péptidos personalizados

No. CAS : 177943-88-3

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
1 mg En stock
5 mg En stock
10 mg En stock
50 mg   Obtener un presupuesto  
100 mg   Obtener un presupuesto  

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Revisión del cliente

Based on 3 publication(s) in Google Scholar

Other Forms of DOTATATE:

DOTATATE Related Antibodies

Top Publications Citing Use of Products

    DOTATATE purchased from MedChemExpress. Usage Cited in: J Nucl Med. 2024 Oct 1;65(10):1619-1625.  [Abstract]

    Total absorbed dose to cell nucleus for range of added activity concentrations of both 161Tb- and 177Lu-labeled DOTATATE (0-1.25 MBq/mL).

    DOTATATE purchased from MedChemExpress. Usage Cited in: J Nucl Med. 2024 Oct 1;65(10):1619-1625.  [Abstract]

    Radiolabeled DOTATATE (1 MBq/mL) resulted in a higher absorbed dose than did radiolabeled DOTA-LM3, because of DOTATATE's higher Bmax and higher internalization.

    DOTATATE purchased from MedChemExpress. Usage Cited in: J Nucl Med. 2024 Oct 1;65(10):1619-1625.  [Abstract]

    The nuclear dose-response data of both [177Lu]Lu- and [161Tb]Tb-DOTATATE (0-25 Gy) were best fitted with a linear model and could be fitted with a common, single curve.

    DOTATATE purchased from MedChemExpress. Usage Cited in: J Nucl Med. 2024 Oct 1;65(10):1619-1625.  [Abstract]

    The saturation binding assay represented total binding and nonspecific binding for different added activity concentrations of [161Tb]Tb-DOTATATE (0-60 nM) with a fixed molar activity of 100 MBq/nmol.

    DOTATATE purchased from MedChemExpress. Usage Cited in: J Nucl Med. 2024 Oct 1;65(10):1619-1625.  [Abstract]

    Clonogenic survival of CA20948 cells after treatment with [161Tb]Tb- and [177Lu]Lu-DOTATATE (0-1.5 MBq/mL) as a function of added activity concentration (MBq/mL).

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    • Actividad biológica

    • Pureza y Documentación

    • Referencias

    • Revisión del cliente

    Descripciòn

    DOTATATE is a DOTA-conjugated peptide. DOTATATE can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide research (PRRT)[1][2][3][4]. DOTATATE can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

    IC50 & Target

    RDC Peptide

     

    Cellular Effect
    Cell Line Type Value Description References
    CHO-K1 IC50
    547 nM
    Compound: DOTA-TOCA
    In vitro inhibition of [125I][Leu8,D-Trp22,Tyr25] somatostatin 28 binding to human somatostatin receptor type 5 expressed in CHO-K1 cells; (n=3)
    In vitro inhibition of [125I][Leu8,D-Trp22,Tyr25] somatostatin 28 binding to human somatostatin receptor type 5 expressed in CHO-K1 cells; (n=3)
    		[PMID: 15828816]
    CHO-K1 IC50
    > 10000 nM
    Compound: DOTA-TOCA
    In vitro inhibition of [125I][Leu8,D-Trp22,Tyr25] somatostatin 28 binding to human somatostatin receptor type 1 expressed in CHO-K1 cells; (n=3)
    In vitro inhibition of [125I][Leu8,D-Trp22,Tyr25] somatostatin 28 binding to human somatostatin receptor type 1 expressed in CHO-K1 cells; (n=3)
    		[PMID: 15828816]
    In Vivo

    177Lu-DOTATATE shows excellent antitumor effects in rats[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Peso molecular

    1435.62

    Fòrmula

    C65H90N14O19S2
    No. CAS
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    {DOTA}-{d-Phe}-Cys-Tyr-{d-Trp}-Lys-Thr-Cys-Thr (Disulfide bridge:Cys2-Cys7)
    Sequence Shortening

    {DOTA}-{d-Phe}-CY-{d-Trp}-KTCT (Disulfide bridge:Cys2-Cys7)
    Envío

    Room temperature in continental US; may vary elsewhere.
    Almacenamiento

    Sealed storage, away from moisture and light

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvente y solubilidad
    In Vitro: 

    DMSO : 100 mg/mL (69.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.6966 mL 3.4828 mL 6.9656 mL
    5 mM 0.1393 mL 0.6966 mL 1.3931 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Calculadora de molaridad

    • Calculadora de dilución

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Pureza y Documentación

    Purity: 99.95%

    SDS (393 KB)

    COA (263 KB) LCMS (97 KB) Elemental Analysis Report (121 KB)

    Instrucciones de manejo (2659 KB)
    Referencias

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 0.6966 mL 3.4828 mL 6.9656 mL 17.4141 mL
    5 mM 0.1393 mL 0.6966 mL 1.3931 mL 3.4828 mL
    10 mM 0.0697 mL 0.3483 mL 0.6966 mL 1.7414 mL
    15 mM 0.0464 mL 0.2322 mL 0.4644 mL 1.1609 mL
    20 mM 0.0348 mL 0.1741 mL 0.3483 mL 0.8707 mL
    25 mM 0.0279 mL 0.1393 mL 0.2786 mL 0.6966 mL
    30 mM 0.0232 mL 0.1161 mL 0.2322 mL 0.5805 mL
    40 mM 0.0174 mL 0.0871 mL 0.1741 mL 0.4354 mL
    50 mM 0.0139 mL 0.0697 mL 0.1393 mL 0.3483 mL
    60 mM 0.0116 mL 0.0580 mL 0.1161 mL 0.2902 mL
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    DOTATATE Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    DOTATATE177943-88-3OxodotreotideRadionuclide-Drug Conjugates (RDCs)radionuclidespositronemissiontomographyPETimagingpeptidereceptorradionuclidetherapyPRRTtumorInhibitorinhibitorinhibit

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    Nombre del producto:
    DOTATATE
    Cat. No.:
    HY-106244
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    SAFETY DATA SHEET (SDS)

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