DSPE-PEG2000-COOH

Name: DSPE-PEG2000-COOH
Brand: MedChemExpress
SKU: HY-170706
Rating: 5.0 (2 reviews)

Cat. No.: HY-170706 Pureté: 99.95%: Fiche technique
COA

SDS
Instruction de manipulation
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DSPE-PEG (2000)-COOH is a pegylated derivative of 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (HY-112530). DSPE-PEG2000-COOH can form micelles for targeted drug delivery.

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DSPE-PEG2000-COOH Chemical Structure

CAS No. : 1445832-74-5

Size	Stock	Quantité
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtenir un devis
500 mg	Obtenir un devis

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Based on 2 publication(s) in Google Scholar

Other Forms of DSPE-PEG2000-COOH:

DSPE-PEG(2000) Succinyl ammonium In-stock

2 Publications Citing Use of MCE DSPE-PEG2000-COOH

Recommandations en vedette

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Activité biologique
Pureté et documentation
Références
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Description

DSPE-PEG (2000)-COOH is a pegylated derivative of 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (HY-112530). DSPE-PEG2000-COOH can form micelles for targeted drug delivery^[1]^[2].

In Vitro

DSPE-PEG2000-COOH can form micelles for targeted drug delivery.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Masse moléculaire

2000 (Average)

Formule

(C₂H₄O)nC₄₈H₉₁N₂O₁₃P

CAS No.

1445832-74-5

Appearance

Solid

Color

White to off-white

SMILES

O=C(CCC(O)=O)NCCOCCOC(NCCOP(OC[C@H](OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)(O)=O)=O.[n]

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

H₂O : 25 mg/mL (Need ultrasonic)

DMSO : 25 mg/mL (ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Calculateur de molarité
Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL; Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL; Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureté et documentation

Purity: 99.95%

Select Batch:

Fiche technique (266 KB) SDS (252 KB)

COA (241 KB) HNMR (328 KB) RP-HPLC (201 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Zhenbao Liu, et al. Aptamer density dependent cellular uptake of lipid-capped polymer nanoparticles for polyvalent
targeted delivery of vinorelbine to cancer cells. RSC Adv., 2015, 5, 16931

[2]. Yubin Liu, et al. Nontoxic Intralipid-DSPE-PEG2000-COOH Nanoparticles as Optical
Coherence Tomography Contrast Agents for Tumor Angiography in
Live Animals. ACS Appl. Nano Mater. 2023, 6, 17691-17697.