2. Immunology/Inflammation
  3. Interleukin Related
  4. Efineptakin alfa

Efineptakin alfa  (Synonyms: NT-17)

製品番号: HY-P99908 純度: 99.70%
COA Technical Support

Efineptakin alfa (NT-17) is a long-acting recombinant human IL-7. Efineptakin alfa supports the proliferation and survival CD4+ and CD8+ cells in both human and mice. Efineptakin alfa can be used for glioblastoma research.

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CAS 番号 : 2026634-47-7

容量 価格（税別） 在庫状況 数量
1 mg $650 在庫あり
5 mg $1820 在庫あり
10 mg $2900 在庫あり
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Interleukin Related アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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製品説明

Efineptakin alfa (NT-17) is a long-acting recombinant human IL-7. Efineptakin alfa supports the proliferation and survival CD4+ and CD8+ cells in both human and mice. Efineptakin alfa can be used for glioblastoma research[1].

IC50 & Target

IL7R

 

体内実験

Efineptakin alfa (10 mg/kg, IM, single) combined with SLC-3010 (1.8 mg/kg, IV, single) inhibits tumor growth in MC38-bearing mice[1].
Efineptakin alfa (10 mg/kg) mitigates RT-related lymphopenia, increases cytotoxic CD8 T lymphocytes systemically and in the tumor, and improves survival in orthotopic glioma-bearing mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice bearing intracranial tumors (GL261 or CT2A)[1]
Dosage: 10 mg/kg
Administration: On the final day of RT (radiotherapy, 1.8 Gy/day × 5 days) completion
Result: Increased T lymphocytes in the lymph nodes, thymus, and spleen, enhanced IFNγ production, and decreased Tregs in the tumor which was associated with a significant increase in survival. Enhanced central memory and effector memory CD8 T cells in lymphoid organs and tumor. Decreased progenitor cells in the bone marrow.
臨床実験
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

90.96 kDa

CAS 番号
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Efineptakin alfa]
輸送条件

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • [IL7 (interleukin 7, IL-7)]1-IGHG4 Fc (Fragment constant)
Biological Activity
  • Immobilized CD127/IL-7RA Protein, Human can bind Efineptakin alfa. The EC50 for this effect is 12.04 ng/mL.
純度とドキュメンテーション
参考文献
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Efineptakin alfa Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Efineptakin alfa2026634-47-7NT-17NT17NT 17Interleukin RelatedILorthotopic gliomaglioblastomaCD8+ T cellsrhIL-7-hyFcInhibitorinhibitorinhibit

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製品名:
Efineptakin alfa
製品番号:
HY-P99908
数量:
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